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An ER translocon for multi-pass membrane protein biogenesis

Membrane proteins with multiple transmembrane domains play critical roles in cell physiology, but little is known about the machinery coordinating their biogenesis at the endoplasmic reticulum. Here we describe a ~ 360 kDa ribosome-associated complex comprising the core Sec61 channel and five access...

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Detalles Bibliográficos
Autores principales:	McGilvray, Philip T, Anghel, S Andrei, Sundaram, Arunkumar, Zhong, Frank, Trnka, Michael J, Fuller, James R, Hu, Hong, Burlingame, Alma L, Keenan, Robert J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505659/ https://www.ncbi.nlm.nih.gov/pubmed/32820719 http://dx.doi.org/10.7554/eLife.56889

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