Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation

Spinocerebellar ataxia type 3 (SCA3) belongs to the family of polyglutamine neurodegenerations. Each disorder stems from the abnormal lengthening of a glutamine repeat in a different protein. Although caused by a similar mutation, polyglutamine disorders are distinct, implicating non-polyglutamine r...

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Detalles Bibliográficos
Autores principales: Johnson, Sean L, Ranxhi, Bedri, Libohova, Kozeta, Tsou, Wei-Ling, Todi, Sokol V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505662/
https://www.ncbi.nlm.nih.gov/pubmed/32955441
http://dx.doi.org/10.7554/eLife.60742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505662/
https://www.ncbi.nlm.nih.gov/pubmed/32955441
http://dx.doi.org/10.7554/eLife.60742

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