Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if uracil incorporations have any positional preference. Here, we aimed to uncover genome-wide alterations in uracil...

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Detalles Bibliográficos
Autores principales: Pálinkás, Hajnalka L, Békési, Angéla, Róna, Gergely, Pongor, Lőrinc, Papp, Gábor, Tihanyi, Gergely, Holub, Eszter, Póti, Ádám, Gemma, Carolina, Ali, Simak, Morten, Michael J, Rothenberg, Eli, Pagano, Michele, Szűts, Dávid, Győrffy, Balázs, Vértessy, Beáta G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505663/
https://www.ncbi.nlm.nih.gov/pubmed/32956035
http://dx.doi.org/10.7554/eLife.60498

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