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Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations
Pain empathy can be evoked by multiple cues, particularly observation of acute pain inflictions or facial expressions of pain. Previous studies suggest that these cues commonly activate the insula and anterior cingulate, yet vicarious pain encompasses pain-specific responses as well as unspecific pr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505665/ https://www.ncbi.nlm.nih.gov/pubmed/32894226 http://dx.doi.org/10.7554/eLife.56929 |
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author | Zhou, Feng Li, Jialin Zhao, Weihua Xu, Lei Zheng, Xiaoxiao Fu, Meina Yao, Shuxia Kendrick, Keith M Wager, Tor D Becker, Benjamin |
author_facet | Zhou, Feng Li, Jialin Zhao, Weihua Xu, Lei Zheng, Xiaoxiao Fu, Meina Yao, Shuxia Kendrick, Keith M Wager, Tor D Becker, Benjamin |
author_sort | Zhou, Feng |
collection | PubMed |
description | Pain empathy can be evoked by multiple cues, particularly observation of acute pain inflictions or facial expressions of pain. Previous studies suggest that these cues commonly activate the insula and anterior cingulate, yet vicarious pain encompasses pain-specific responses as well as unspecific processes (e.g. arousal) and overlapping activations are not sufficient to determine process-specific shared neural representations. We employed multivariate pattern analyses to fMRI data acquired during observation of noxious stimulation of body limbs (NS) and painful facial expressions (FE) and found spatially and functionally similar cross-modality (NS versus FE) whole-brain vicarious pain-predictive patterns. Further analyses consistently identified shared neural representations in the bilateral mid-insula. The vicarious pain patterns were not sensitive to respond to non-painful high-arousal negative stimuli but predicted self-experienced thermal pain. Finally, a domain-general vicarious pain pattern predictive of self-experienced pain but not arousal was developed. Our findings demonstrate shared pain-associated neural representations of vicarious pain. |
format | Online Article Text |
id | pubmed-7505665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-75056652020-09-23 Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations Zhou, Feng Li, Jialin Zhao, Weihua Xu, Lei Zheng, Xiaoxiao Fu, Meina Yao, Shuxia Kendrick, Keith M Wager, Tor D Becker, Benjamin eLife Neuroscience Pain empathy can be evoked by multiple cues, particularly observation of acute pain inflictions or facial expressions of pain. Previous studies suggest that these cues commonly activate the insula and anterior cingulate, yet vicarious pain encompasses pain-specific responses as well as unspecific processes (e.g. arousal) and overlapping activations are not sufficient to determine process-specific shared neural representations. We employed multivariate pattern analyses to fMRI data acquired during observation of noxious stimulation of body limbs (NS) and painful facial expressions (FE) and found spatially and functionally similar cross-modality (NS versus FE) whole-brain vicarious pain-predictive patterns. Further analyses consistently identified shared neural representations in the bilateral mid-insula. The vicarious pain patterns were not sensitive to respond to non-painful high-arousal negative stimuli but predicted self-experienced thermal pain. Finally, a domain-general vicarious pain pattern predictive of self-experienced pain but not arousal was developed. Our findings demonstrate shared pain-associated neural representations of vicarious pain. eLife Sciences Publications, Ltd 2020-09-07 /pmc/articles/PMC7505665/ /pubmed/32894226 http://dx.doi.org/10.7554/eLife.56929 Text en © 2020, Zhou et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Zhou, Feng Li, Jialin Zhao, Weihua Xu, Lei Zheng, Xiaoxiao Fu, Meina Yao, Shuxia Kendrick, Keith M Wager, Tor D Becker, Benjamin Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations |
title | Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations |
title_full | Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations |
title_fullStr | Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations |
title_full_unstemmed | Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations |
title_short | Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations |
title_sort | empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505665/ https://www.ncbi.nlm.nih.gov/pubmed/32894226 http://dx.doi.org/10.7554/eLife.56929 |
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