Cargando…

Prevalence of Hypothyroidism in a Large Sample of Patients with Obesity Hypoventilation Syndrome

PURPOSE: Data on hypothyroidism in patients with obesity hypoventilation syndrome (OHS) are scarce. This study assessed the prevalence of hypothyroidism among a large group of patients with OHS. PATIENTS AND METHODS: This was a prospective observational study of 308 consecutive patients with OHS see...

Descripción completa

Detalles Bibliográficos
Autores principales: BaHammam, Ahmed S, Aleissi, Salih, Olaish, Awad H, Almeneessier, Aljohara S, Jammah, Anwar A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505711/
https://www.ncbi.nlm.nih.gov/pubmed/32982523
http://dx.doi.org/10.2147/NSS.S263959
_version_ 1783584871451459584
author BaHammam, Ahmed S
Aleissi, Salih
Olaish, Awad H
Almeneessier, Aljohara S
Jammah, Anwar A
author_facet BaHammam, Ahmed S
Aleissi, Salih
Olaish, Awad H
Almeneessier, Aljohara S
Jammah, Anwar A
author_sort BaHammam, Ahmed S
collection PubMed
description PURPOSE: Data on hypothyroidism in patients with obesity hypoventilation syndrome (OHS) are scarce. This study assessed the prevalence of hypothyroidism among a large group of patients with OHS. PATIENTS AND METHODS: This was a prospective observational study of 308 consecutive patients with OHS seen between January 2002 and December 2018. Serum thyroid-stimulating hormone (TSH) and free-thyroxine (FT4) levels were measured in all patients. The OHS patients were compared with 445 patients with obstructive sleep apnoea (OSA) matched for age, sex, and body mass index (BMI). RESULTS: The OHS patients had a mean age of 55.1 ± 13.8 years and a BMI of 43.9 ± 14.8 kg/m(2); apnoea hypopnea index was ≥30 events/hr in 222 (72%). Clinical hypothyroidism was diagnosed in 58 (18.8%) of the OHS patients; only two cases (0.6%) were diagnosed in the sleep disorders clinic (newly diagnosed cases). Subclinical hypothyroidism was diagnosed in 19 (6.2%) of the OHS patients based on elevated TSH and normal FT4 levels; all cases were newly diagnosed. A logistic regression model identified female sex as the only predictor of clinical hypothyroidism in OHS patients (odds ratio: 2.801 [1.386–5.662], p = 0.004). There was no significant difference in clinical hypothyroidism prevalence between the OHS and OSA patients; however, subclinical hypothyroidism was more common in OHS than in OSA patients (6.2% vs 2.9%, respectively, p = 0.03). CONCLUSION: Clinical hypothyroidism was prevalent among patients with OHS; however, newly diagnosed cases of clinical hypothyroidism were relatively low. Female sex was the only predictor of clinical hypothyroidism.
format Online
Article
Text
id pubmed-7505711
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-75057112020-09-24 Prevalence of Hypothyroidism in a Large Sample of Patients with Obesity Hypoventilation Syndrome BaHammam, Ahmed S Aleissi, Salih Olaish, Awad H Almeneessier, Aljohara S Jammah, Anwar A Nat Sci Sleep Original Research PURPOSE: Data on hypothyroidism in patients with obesity hypoventilation syndrome (OHS) are scarce. This study assessed the prevalence of hypothyroidism among a large group of patients with OHS. PATIENTS AND METHODS: This was a prospective observational study of 308 consecutive patients with OHS seen between January 2002 and December 2018. Serum thyroid-stimulating hormone (TSH) and free-thyroxine (FT4) levels were measured in all patients. The OHS patients were compared with 445 patients with obstructive sleep apnoea (OSA) matched for age, sex, and body mass index (BMI). RESULTS: The OHS patients had a mean age of 55.1 ± 13.8 years and a BMI of 43.9 ± 14.8 kg/m(2); apnoea hypopnea index was ≥30 events/hr in 222 (72%). Clinical hypothyroidism was diagnosed in 58 (18.8%) of the OHS patients; only two cases (0.6%) were diagnosed in the sleep disorders clinic (newly diagnosed cases). Subclinical hypothyroidism was diagnosed in 19 (6.2%) of the OHS patients based on elevated TSH and normal FT4 levels; all cases were newly diagnosed. A logistic regression model identified female sex as the only predictor of clinical hypothyroidism in OHS patients (odds ratio: 2.801 [1.386–5.662], p = 0.004). There was no significant difference in clinical hypothyroidism prevalence between the OHS and OSA patients; however, subclinical hypothyroidism was more common in OHS than in OSA patients (6.2% vs 2.9%, respectively, p = 0.03). CONCLUSION: Clinical hypothyroidism was prevalent among patients with OHS; however, newly diagnosed cases of clinical hypothyroidism were relatively low. Female sex was the only predictor of clinical hypothyroidism. Dove 2020-09-16 /pmc/articles/PMC7505711/ /pubmed/32982523 http://dx.doi.org/10.2147/NSS.S263959 Text en © 2020 BaHammam et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
BaHammam, Ahmed S
Aleissi, Salih
Olaish, Awad H
Almeneessier, Aljohara S
Jammah, Anwar A
Prevalence of Hypothyroidism in a Large Sample of Patients with Obesity Hypoventilation Syndrome
title Prevalence of Hypothyroidism in a Large Sample of Patients with Obesity Hypoventilation Syndrome
title_full Prevalence of Hypothyroidism in a Large Sample of Patients with Obesity Hypoventilation Syndrome
title_fullStr Prevalence of Hypothyroidism in a Large Sample of Patients with Obesity Hypoventilation Syndrome
title_full_unstemmed Prevalence of Hypothyroidism in a Large Sample of Patients with Obesity Hypoventilation Syndrome
title_short Prevalence of Hypothyroidism in a Large Sample of Patients with Obesity Hypoventilation Syndrome
title_sort prevalence of hypothyroidism in a large sample of patients with obesity hypoventilation syndrome
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505711/
https://www.ncbi.nlm.nih.gov/pubmed/32982523
http://dx.doi.org/10.2147/NSS.S263959
work_keys_str_mv AT bahammamahmeds prevalenceofhypothyroidisminalargesampleofpatientswithobesityhypoventilationsyndrome
AT aleissisalih prevalenceofhypothyroidisminalargesampleofpatientswithobesityhypoventilationsyndrome
AT olaishawadh prevalenceofhypothyroidisminalargesampleofpatientswithobesityhypoventilationsyndrome
AT almeneessieraljoharas prevalenceofhypothyroidisminalargesampleofpatientswithobesityhypoventilationsyndrome
AT jammahanwara prevalenceofhypothyroidisminalargesampleofpatientswithobesityhypoventilationsyndrome