Cargando…

LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma

BACKGROUND & AIMS: Gemcitabine resistance is rapidly acquired by pancreatic ductal adenocarcinoma (PDAC) patients. Novel approaches that predict the gemcitabine response of patients and enhance gemcitabine chemosensitivity are important to improve patient survival. We aimed to identify genes as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Yin-Xin, Li, Chi Han, Li, Guolin, Feng, Huiyi, Xia, Tian, Wong, Chi Hin, Fung, Frederic Khe Cheong, Tong, Joanna Hung-Man, To, Ka-Fai, Chen, Rufu, Chen, Yangchao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505810/ https://www.ncbi.nlm.nih.gov/pubmed/32615164 http://dx.doi.org/10.1016/j.jcmgh.2020.06.009

Ejemplares similares

CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein
por: Wong, Chi Hin, et al.
Publicado: (2022)

Identification of GRIN2D as a novel therapeutic target in pancreatic ductal adenocarcinoma
por: Wang, Jiatong, et al.
Publicado: (2023)

Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia
por: Eifert, Theresa, et al.
Publicado: (2023)

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML
por: Heidel, Florian H., et al.
Publicado: (2013)

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration
por: Greenwood, Erin, et al.
Publicado: (2016)

Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases
por: Desuki, Alexander, et al.
Publicado: (2019)

Targeting OSMR in glioma stem cells
por: Mohan, Sushmetha, et al.
Publicado: (2017)

Characterization of an Osmr Conditional Knockout Mouse Model
por: Schwartz, Logan S., et al.
Publicado: (2023)

Silencing of LLGL2 Suppresses the Estradiol-Induced BPH-1 Cell Proliferation through the Regulation of Autophagy
por: Kim, Kyung-Hyun, et al.
Publicado: (2022)

Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer
por: Wei, Lusheng, et al.
Publicado: (2018)

Correction: Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer
por: Wei, Lusheng, et al.
Publicado: (2021)

OsMre11 Is Required for Mitosis during Rice Growth and Development
por: Shen, Miaomiao, et al.
Publicado: (2020)

Gemcitabine Compared With Gemcitabine and S-1 Combination Therapy in Advanced Pancreatic Cancer: A Systematic Review and Meta-Analysis
por: Li, Doudou, et al.
Publicado: (2015)

Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation
por: Wei, Lusheng, et al.
Publicado: (2021)

Gfap and Osmr regulation by BRG1 and STAT3 via interchromosomal gene clustering in astrocytes
por: Ito, Kenji, et al.
Publicado: (2018)

OSM/OSMR and Interleukin 6 Family Cytokines in Physiological and Pathological Condition
por: Lantieri, Francesca, et al.
Publicado: (2022)

REPURPOSING OF FDA APPROVED COMPOUNDS TO INHIBIT OSM/OSMR SIGNALING IN GLIOBLASTOMA
por: Lotfipour, Farzaneh, et al.
Publicado: (2023)

circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis
por: Hu, Chonghui, et al.
Publicado: (2022)

Overexpression of microRNA-183 promotes apoptosis of substantia nigra neurons via the inhibition of OSMR in a mouse model of Parkinson’s disease
por: Gao, Jin-Xia, et al.
Publicado: (2019)

A simple and rapid colorimetric detection of serum lncRNA biomarkers for diagnosis of pancreatic cancer
por: Lou, Ut Kei, et al.
Publicado: (2020)

FEZF1-AS1/miR-107/ZNF312B axis facilitates progression and Warburg effect in pancreatic ductal adenocarcinoma
por: Ye, Huilin, et al.
Publicado: (2018)

The establishment of CDK9/RNA PolII/H3K4me3/DNA methylation feedback promotes HOTAIR expression by RNA elongation enhancement in cancer
por: Wong, Chi Hin, et al.
Publicado: (2022)

OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation
por: Sharanek, Ahmad, et al.
Publicado: (2020)

The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling
por: Bachetti, Tiziana, et al.
Publicado: (2021)

DDRE-21. THE FUNCTION OF MITOCHONDRIAL OSMR IN GLIOMA STEM CELL RESPIRATION AND GLIOBLASTOMA PATHOGENESIS
por: Jahani-Asl, Arezu, et al.
Publicado: (2021)

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis
por: Lee, Brian Y., et al.
Publicado: (2021)

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma
por: Ye, Huilin, et al.
Publicado: (2018)

miR-665通过靶向调控LLGL1促进小细胞肺癌生物学行为的研究
Publicado: (2020)

Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
por: Valussi, Melissa, et al.
Publicado: (2021)

SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p
por: Zhang, Shihui, et al.
Publicado: (2022)

Efficacy and safety of gemcitabine plus S-1 vs. gemcitabine plus nab-paclitaxel in treatment-naïve advanced pancreatic ductal adenocarcinoma
por: Zhu, Zhou, et al.
Publicado: (2023)

Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer
por: Hisada, Tomoka, et al.
Publicado: (2022)

OSMR gene effect on the pathogenesis of chronic autoimmune Urticaria via the JAK/STAT3 pathway
por: Luo, Xiao-Yan, et al.
Publicado: (2018)

Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars
por: Lee, Mi Young, et al.
Publicado: (2018)

Common Variants Associated With OSMR Expression Contribute to Carotid Plaque Vulnerability, but Not to Cardiovascular Disease in Humans
por: van Keulen, Danielle, et al.
Publicado: (2021)

Novel crosstalk between KLF4 and ZEB1 regulates gemcitabine resistance in pancreatic ductal adenocarcinoma
por: Wang, Zhiyi, et al.
Publicado: (2020)

Molecular profile of pure squamous cell carcinoma of the bladder identifies major roles for OSMR and YAP signalling
por: Hurst, Carolyn D, et al.
Publicado: (2022)

Real-world outcomes of adjuvant gemcitabine versus gemcitabine plus capecitabine for resected pancreatic ductal adenocarcinoma
por: Kang, Sora, et al.
Publicado: (2022)

Real‐world evidence of adjuvant gemcitabine plus capecitabine vs gemcitabine monotherapy for pancreatic ductal adenocarcinoma
por: de Jong, Evelien J. M., et al.
Publicado: (2021)

Comparison of adjuvant gemcitabine plus S-1 with S-1 monotherapy for pancreatic ductal adenocarcinoma: Retrospective real-world data
por: Tang, Hui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jdd322licmg1toqag0q8285s70