Cargando…
Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study
INTRODUCTION: The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination of staging and grade of differentiation still evidently represents a clinical problem. SOD level raises at a certain staging and reduce at a certain grade of differentiation. F...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505864/ https://www.ncbi.nlm.nih.gov/pubmed/32994983 http://dx.doi.org/10.1016/j.amsu.2020.08.032 |
_version_ | 1783584903548370944 |
---|---|
author | Warsinggih Irawan, Budi Labeda, Ibrahim Lusikooy, Ronald Erasio Sampetoding, Samuel Kusuma, M. Ihwan Uwuratuw, Julianus Aboyaman Syarifuddin, Erwin Prihantono Faruk, Muhammad |
author_facet | Warsinggih Irawan, Budi Labeda, Ibrahim Lusikooy, Ronald Erasio Sampetoding, Samuel Kusuma, M. Ihwan Uwuratuw, Julianus Aboyaman Syarifuddin, Erwin Prihantono Faruk, Muhammad |
author_sort | Warsinggih |
collection | PubMed |
description | INTRODUCTION: The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination of staging and grade of differentiation still evidently represents a clinical problem. SOD level raises at a certain staging and reduce at a certain grade of differentiation. For that reason, this study aimed to assess the association between SOD and the variables analyzed in this study. MATERIALS AND METHODS: This study was observational study using a cross-sectional research design aimed to measure the association between SOD and staging as well as grade of differentiation in CRC incidence. The study was conducted in our institution from January until March 2018. RESULTS: Statistical analyses of the data derived from the laboratory indicated that age and histopathological examination (TNM staging) had statistically significant correlation with SOD1 level. This significant correlation was proven from results of the statistical analyses of each variable at p = 0.039 (age) and p = 0.001 (TNM staging) respectively. Subsequent tests concerning the correlation between age and TNM staging on SOD1 level revealed that the study samples in the category of 30–49 age years old showed statistically significant correlation with SOD1 level with p = 0.009. CONCLUSION: The increase of grade of differentiation was proportional to the increase of SOD1 level as antioxidant against cancer in CRC patients. |
format | Online Article Text |
id | pubmed-7505864 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75058642020-09-28 Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study Warsinggih Irawan, Budi Labeda, Ibrahim Lusikooy, Ronald Erasio Sampetoding, Samuel Kusuma, M. Ihwan Uwuratuw, Julianus Aboyaman Syarifuddin, Erwin Prihantono Faruk, Muhammad Ann Med Surg (Lond) Original Research INTRODUCTION: The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination of staging and grade of differentiation still evidently represents a clinical problem. SOD level raises at a certain staging and reduce at a certain grade of differentiation. For that reason, this study aimed to assess the association between SOD and the variables analyzed in this study. MATERIALS AND METHODS: This study was observational study using a cross-sectional research design aimed to measure the association between SOD and staging as well as grade of differentiation in CRC incidence. The study was conducted in our institution from January until March 2018. RESULTS: Statistical analyses of the data derived from the laboratory indicated that age and histopathological examination (TNM staging) had statistically significant correlation with SOD1 level. This significant correlation was proven from results of the statistical analyses of each variable at p = 0.039 (age) and p = 0.001 (TNM staging) respectively. Subsequent tests concerning the correlation between age and TNM staging on SOD1 level revealed that the study samples in the category of 30–49 age years old showed statistically significant correlation with SOD1 level with p = 0.009. CONCLUSION: The increase of grade of differentiation was proportional to the increase of SOD1 level as antioxidant against cancer in CRC patients. Elsevier 2020-09-02 /pmc/articles/PMC7505864/ /pubmed/32994983 http://dx.doi.org/10.1016/j.amsu.2020.08.032 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Research Warsinggih Irawan, Budi Labeda, Ibrahim Lusikooy, Ronald Erasio Sampetoding, Samuel Kusuma, M. Ihwan Uwuratuw, Julianus Aboyaman Syarifuddin, Erwin Prihantono Faruk, Muhammad Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study |
title | Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study |
title_full | Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study |
title_fullStr | Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study |
title_full_unstemmed | Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study |
title_short | Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study |
title_sort | association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: a cross-sectional study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505864/ https://www.ncbi.nlm.nih.gov/pubmed/32994983 http://dx.doi.org/10.1016/j.amsu.2020.08.032 |
work_keys_str_mv | AT warsinggih associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT irawanbudi associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT labedaibrahim associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT lusikooyronalderasio associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT sampetodingsamuel associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT kusumamihwan associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT uwuratuwjulianusaboyaman associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT syarifuddinerwin associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT prihantono associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy AT farukmuhammad associationofsuperoxidedismutaseenzymewithstagingandgradeofdifferentiationcolorectalcanceracrosssectionalstudy |