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Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study

INTRODUCTION: The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination of staging and grade of differentiation still evidently represents a clinical problem. SOD level raises at a certain staging and reduce at a certain grade of differentiation. F...

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Autores principales: Warsinggih, Irawan, Budi, Labeda, Ibrahim, Lusikooy, Ronald Erasio, Sampetoding, Samuel, Kusuma, M. Ihwan, Uwuratuw, Julianus Aboyaman, Syarifuddin, Erwin, Prihantono, Faruk, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505864/
https://www.ncbi.nlm.nih.gov/pubmed/32994983
http://dx.doi.org/10.1016/j.amsu.2020.08.032
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author Warsinggih
Irawan, Budi
Labeda, Ibrahim
Lusikooy, Ronald Erasio
Sampetoding, Samuel
Kusuma, M. Ihwan
Uwuratuw, Julianus Aboyaman
Syarifuddin, Erwin
Prihantono
Faruk, Muhammad
author_facet Warsinggih
Irawan, Budi
Labeda, Ibrahim
Lusikooy, Ronald Erasio
Sampetoding, Samuel
Kusuma, M. Ihwan
Uwuratuw, Julianus Aboyaman
Syarifuddin, Erwin
Prihantono
Faruk, Muhammad
author_sort Warsinggih
collection PubMed
description INTRODUCTION: The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination of staging and grade of differentiation still evidently represents a clinical problem. SOD level raises at a certain staging and reduce at a certain grade of differentiation. For that reason, this study aimed to assess the association between SOD and the variables analyzed in this study. MATERIALS AND METHODS: This study was observational study using a cross-sectional research design aimed to measure the association between SOD and staging as well as grade of differentiation in CRC incidence. The study was conducted in our institution from January until March 2018. RESULTS: Statistical analyses of the data derived from the laboratory indicated that age and histopathological examination (TNM staging) had statistically significant correlation with SOD1 level. This significant correlation was proven from results of the statistical analyses of each variable at p = 0.039 (age) and p = 0.001 (TNM staging) respectively. Subsequent tests concerning the correlation between age and TNM staging on SOD1 level revealed that the study samples in the category of 30–49 age years old showed statistically significant correlation with SOD1 level with p = 0.009. CONCLUSION: The increase of grade of differentiation was proportional to the increase of SOD1 level as antioxidant against cancer in CRC patients.
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spelling pubmed-75058642020-09-28 Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study Warsinggih Irawan, Budi Labeda, Ibrahim Lusikooy, Ronald Erasio Sampetoding, Samuel Kusuma, M. Ihwan Uwuratuw, Julianus Aboyaman Syarifuddin, Erwin Prihantono Faruk, Muhammad Ann Med Surg (Lond) Original Research INTRODUCTION: The increase of superoxide dismutase (SOD) level in colorectal cancer (CRC) patients based on the examination of staging and grade of differentiation still evidently represents a clinical problem. SOD level raises at a certain staging and reduce at a certain grade of differentiation. For that reason, this study aimed to assess the association between SOD and the variables analyzed in this study. MATERIALS AND METHODS: This study was observational study using a cross-sectional research design aimed to measure the association between SOD and staging as well as grade of differentiation in CRC incidence. The study was conducted in our institution from January until March 2018. RESULTS: Statistical analyses of the data derived from the laboratory indicated that age and histopathological examination (TNM staging) had statistically significant correlation with SOD1 level. This significant correlation was proven from results of the statistical analyses of each variable at p = 0.039 (age) and p = 0.001 (TNM staging) respectively. Subsequent tests concerning the correlation between age and TNM staging on SOD1 level revealed that the study samples in the category of 30–49 age years old showed statistically significant correlation with SOD1 level with p = 0.009. CONCLUSION: The increase of grade of differentiation was proportional to the increase of SOD1 level as antioxidant against cancer in CRC patients. Elsevier 2020-09-02 /pmc/articles/PMC7505864/ /pubmed/32994983 http://dx.doi.org/10.1016/j.amsu.2020.08.032 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
Warsinggih
Irawan, Budi
Labeda, Ibrahim
Lusikooy, Ronald Erasio
Sampetoding, Samuel
Kusuma, M. Ihwan
Uwuratuw, Julianus Aboyaman
Syarifuddin, Erwin
Prihantono
Faruk, Muhammad
Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study
title Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study
title_full Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study
title_fullStr Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study
title_full_unstemmed Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study
title_short Association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: A cross-sectional study
title_sort association of superoxide dismutase enzyme with staging and grade of differentiation colorectal cancer: a cross-sectional study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505864/
https://www.ncbi.nlm.nih.gov/pubmed/32994983
http://dx.doi.org/10.1016/j.amsu.2020.08.032
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