HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis

In chronic pancreatitis, PSCs are activated by proinflammatory cytokines to induce pancreatic fibrogenesis. HDAC inhibition protected against the pancreatic fibrosis and the apoptosis of PSCs through induced apoptosis and depressed inflammation. In our study, we found that miR-15 and miR-16 decrease...

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Detalles Bibliográficos
Autores principales: Ji, Ting, Feng, Weiguang, Zhang, Xiangcheng, Zang, Kui, Zhu, Xingxing, Shang, Futai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505886/
https://www.ncbi.nlm.nih.gov/pubmed/32524326
http://dx.doi.org/10.1007/s13577-020-00387-x

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