Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

The nucleosome is the basic structural repeating unit of chromatin. DNA damage and cell apoptosis release nucleosomes into the blood circulatory system, and increased levels of circulating nucleosomes have been observed to be related to inflammation and autoimmune diseases. However, how circulating...

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Detalles Bibliográficos
Autores principales: Wang, Huawei, Zang, Chuanlong, Ren, Mengtian, Shang, Mengdi, Wang, Zhenghua, Peng, Xuemei, Zhang, Qiangzhe, Wen, Xin, Xi, Zhen, Zhou, Chuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505961/
https://www.ncbi.nlm.nih.gov/pubmed/32958884
http://dx.doi.org/10.1038/s41598-020-72393-w

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