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Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis
Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506051/ https://www.ncbi.nlm.nih.gov/pubmed/33013647 http://dx.doi.org/10.3389/fneur.2020.00978 |
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author | Engen, Phillip A. Zaferiou, Antonia Rasmussen, Heather Naqib, Ankur Green, Stefan J. Fogg, Louis F. Forsyth, Christopher B. Raeisi, Shohreh Hamaker, Bruce Keshavarzian, Ali |
author_facet | Engen, Phillip A. Zaferiou, Antonia Rasmussen, Heather Naqib, Ankur Green, Stefan J. Fogg, Louis F. Forsyth, Christopher B. Raeisi, Shohreh Hamaker, Bruce Keshavarzian, Ali |
author_sort | Engen, Phillip A. |
collection | PubMed |
description | Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-subject longitudinal study provides evidence of potential importance of intestinal microbiota in the pathogenesis of MS, and scientific rationale to help design future randomized controlled trials assessing FMT in RRMS patients. |
format | Online Article Text |
id | pubmed-7506051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75060512020-10-02 Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis Engen, Phillip A. Zaferiou, Antonia Rasmussen, Heather Naqib, Ankur Green, Stefan J. Fogg, Louis F. Forsyth, Christopher B. Raeisi, Shohreh Hamaker, Bruce Keshavarzian, Ali Front Neurol Neurology Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-subject longitudinal study provides evidence of potential importance of intestinal microbiota in the pathogenesis of MS, and scientific rationale to help design future randomized controlled trials assessing FMT in RRMS patients. Frontiers Media S.A. 2020-09-08 /pmc/articles/PMC7506051/ /pubmed/33013647 http://dx.doi.org/10.3389/fneur.2020.00978 Text en Copyright © 2020 Engen, Zaferiou, Rasmussen, Naqib, Green, Fogg, Forsyth, Raeisi, Hamaker and Keshavarzian. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Engen, Phillip A. Zaferiou, Antonia Rasmussen, Heather Naqib, Ankur Green, Stefan J. Fogg, Louis F. Forsyth, Christopher B. Raeisi, Shohreh Hamaker, Bruce Keshavarzian, Ali Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis |
title | Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis |
title_full | Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis |
title_fullStr | Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis |
title_full_unstemmed | Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis |
title_short | Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis |
title_sort | single-arm, non-randomized, time series, single-subject study of fecal microbiota transplantation in multiple sclerosis |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506051/ https://www.ncbi.nlm.nih.gov/pubmed/33013647 http://dx.doi.org/10.3389/fneur.2020.00978 |
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