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Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis

Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep...

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Autores principales: Engen, Phillip A., Zaferiou, Antonia, Rasmussen, Heather, Naqib, Ankur, Green, Stefan J., Fogg, Louis F., Forsyth, Christopher B., Raeisi, Shohreh, Hamaker, Bruce, Keshavarzian, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506051/
https://www.ncbi.nlm.nih.gov/pubmed/33013647
http://dx.doi.org/10.3389/fneur.2020.00978
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author Engen, Phillip A.
Zaferiou, Antonia
Rasmussen, Heather
Naqib, Ankur
Green, Stefan J.
Fogg, Louis F.
Forsyth, Christopher B.
Raeisi, Shohreh
Hamaker, Bruce
Keshavarzian, Ali
author_facet Engen, Phillip A.
Zaferiou, Antonia
Rasmussen, Heather
Naqib, Ankur
Green, Stefan J.
Fogg, Louis F.
Forsyth, Christopher B.
Raeisi, Shohreh
Hamaker, Bruce
Keshavarzian, Ali
author_sort Engen, Phillip A.
collection PubMed
description Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-subject longitudinal study provides evidence of potential importance of intestinal microbiota in the pathogenesis of MS, and scientific rationale to help design future randomized controlled trials assessing FMT in RRMS patients.
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spelling pubmed-75060512020-10-02 Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis Engen, Phillip A. Zaferiou, Antonia Rasmussen, Heather Naqib, Ankur Green, Stefan J. Fogg, Louis F. Forsyth, Christopher B. Raeisi, Shohreh Hamaker, Bruce Keshavarzian, Ali Front Neurol Neurology Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-subject longitudinal study provides evidence of potential importance of intestinal microbiota in the pathogenesis of MS, and scientific rationale to help design future randomized controlled trials assessing FMT in RRMS patients. Frontiers Media S.A. 2020-09-08 /pmc/articles/PMC7506051/ /pubmed/33013647 http://dx.doi.org/10.3389/fneur.2020.00978 Text en Copyright © 2020 Engen, Zaferiou, Rasmussen, Naqib, Green, Fogg, Forsyth, Raeisi, Hamaker and Keshavarzian. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Engen, Phillip A.
Zaferiou, Antonia
Rasmussen, Heather
Naqib, Ankur
Green, Stefan J.
Fogg, Louis F.
Forsyth, Christopher B.
Raeisi, Shohreh
Hamaker, Bruce
Keshavarzian, Ali
Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis
title Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis
title_full Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis
title_fullStr Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis
title_full_unstemmed Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis
title_short Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis
title_sort single-arm, non-randomized, time series, single-subject study of fecal microbiota transplantation in multiple sclerosis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506051/
https://www.ncbi.nlm.nih.gov/pubmed/33013647
http://dx.doi.org/10.3389/fneur.2020.00978
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