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The Probable, Possible, and Novel Functions of ERp29
The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulato...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506106/ https://www.ncbi.nlm.nih.gov/pubmed/33013490 http://dx.doi.org/10.3389/fphys.2020.574339 |
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author | Brecker, Margaret Khakhina, Svetlana Schubert, Tyler J. Thompson, Zachary Rubenstein, Ronald C. |
author_facet | Brecker, Margaret Khakhina, Svetlana Schubert, Tyler J. Thompson, Zachary Rubenstein, Ronald C. |
author_sort | Brecker, Margaret |
collection | PubMed |
description | The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial sodium channel (ENaC), thyroglobulin, connexin 43 hemichannels, and proinsulin. ERp29 is hypothesized to promote ER to cis-Golgi cargo protein transport via COP II machinery through its interactions with the KDEL receptor; this interaction may facilitate the loading of ERp29 clients into COP II vesicles. ERp29 also plays a role in ER stress (ERS) and the unfolded protein response (UPR) and is implicated in oncogenesis. Here, we review the vast array of ERp29’s clients, its role as an ER to Golgi escort protein, and further suggest ERp29 as a potential target for therapies related to diseases of protein misfolding and mistrafficking. |
format | Online Article Text |
id | pubmed-7506106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75061062020-10-02 The Probable, Possible, and Novel Functions of ERp29 Brecker, Margaret Khakhina, Svetlana Schubert, Tyler J. Thompson, Zachary Rubenstein, Ronald C. Front Physiol Physiology The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial sodium channel (ENaC), thyroglobulin, connexin 43 hemichannels, and proinsulin. ERp29 is hypothesized to promote ER to cis-Golgi cargo protein transport via COP II machinery through its interactions with the KDEL receptor; this interaction may facilitate the loading of ERp29 clients into COP II vesicles. ERp29 also plays a role in ER stress (ERS) and the unfolded protein response (UPR) and is implicated in oncogenesis. Here, we review the vast array of ERp29’s clients, its role as an ER to Golgi escort protein, and further suggest ERp29 as a potential target for therapies related to diseases of protein misfolding and mistrafficking. Frontiers Media S.A. 2020-09-08 /pmc/articles/PMC7506106/ /pubmed/33013490 http://dx.doi.org/10.3389/fphys.2020.574339 Text en Copyright © 2020 Brecker, Khakhina, Schubert, Thompson and Rubenstein. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Brecker, Margaret Khakhina, Svetlana Schubert, Tyler J. Thompson, Zachary Rubenstein, Ronald C. The Probable, Possible, and Novel Functions of ERp29 |
title | The Probable, Possible, and Novel Functions of ERp29 |
title_full | The Probable, Possible, and Novel Functions of ERp29 |
title_fullStr | The Probable, Possible, and Novel Functions of ERp29 |
title_full_unstemmed | The Probable, Possible, and Novel Functions of ERp29 |
title_short | The Probable, Possible, and Novel Functions of ERp29 |
title_sort | probable, possible, and novel functions of erp29 |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506106/ https://www.ncbi.nlm.nih.gov/pubmed/33013490 http://dx.doi.org/10.3389/fphys.2020.574339 |
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