The Immunologic Effect of Early Intravenous Two and Four Gram Bolus Dosing of Tranexamic Acid Compared to Placebo in Patients With Severe Traumatic Bleeding (TAMPITI): A Randomized, Double-Blind, Placebo-Controlled, Single-Center Trial

BACKGROUND: The hemostatic properties of tranexamic acid (TXA) are well described, but the immunological effects of TXA administration after traumatic injury have not been thoroughly examined. We hypothesized TXA would reduce monocyte activation in bleeding trauma patients with severe injury. METHOD...

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Detalles Bibliográficos
Autores principales: Spinella, Philip C., Thomas, Kimberly A., Turnbull, Isaiah R., Fuchs, Anja, Bochicchio, Kelly, Schuerer, Douglas, Reese, Stacey, Coleoglou Centeno, Adrian A., Horn, Christopher B., Baty, Jack, Shea, Susan M., Meledeo, M. Adam, Pusateri, Anthony E., Levy, Jerrold H., Cap, Andrew P., Bochicchio, Grant V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506112/
https://www.ncbi.nlm.nih.gov/pubmed/33013880
http://dx.doi.org/10.3389/fimmu.2020.02085

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