Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinic...

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Autores principales: Selmin, Ornella I., Donovan, Micah G., Stillwater, Barbara J., Neumayer, Leigh, Romagnolo, Donato F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Nutrition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506147/
https://www.ncbi.nlm.nih.gov/pubmed/33015128
http://dx.doi.org/10.3389/fnut.2020.00159
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author Selmin, Ornella I.
Donovan, Micah G.
Stillwater, Barbara J.
Neumayer, Leigh
Romagnolo, Donato F.
author_facet Selmin, Ornella I.
Donovan, Micah G.
Stillwater, Barbara J.
Neumayer, Leigh
Romagnolo, Donato F.
author_sort Selmin, Ornella I.
collection PubMed
description Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC.
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spelling pubmed-75061472020-10-02 Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer Selmin, Ornella I. Donovan, Micah G. Stillwater, Barbara J. Neumayer, Leigh Romagnolo, Donato F. Front Nutr Nutrition Triple negative breast cancer (TNBC) represents a highly heterogeneous group of breast cancers, lacking expression of the estrogen (ER) and progesterone (PR) receptors, and human epidermal growth factor receptor 2 (HER2). TNBC are characterized by a high level of mutation and metastasis, poor clinical outcomes and overall survival. Here, we review the epigenetic mechanisms of regulation involved in cell pathways disrupted in TNBC, with particular emphasis on dietary food components that may be exploited for the development of effective strategies for management of TNBC. Frontiers Media S.A. 2020-09-08 /pmc/articles/PMC7506147/ /pubmed/33015128 http://dx.doi.org/10.3389/fnut.2020.00159 Text en Copyright © 2020 Selmin, Donovan, Stillwater, Neumayer and Romagnolo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Selmin, Ornella I.
Donovan, Micah G.
Stillwater, Barbara J.
Neumayer, Leigh
Romagnolo, Donato F.
Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
title Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
title_full Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
title_fullStr Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
title_full_unstemmed Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
title_short Epigenetic Regulation and Dietary Control of Triple Negative Breast Cancer
title_sort epigenetic regulation and dietary control of triple negative breast cancer
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506147/
https://www.ncbi.nlm.nih.gov/pubmed/33015128
http://dx.doi.org/10.3389/fnut.2020.00159
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