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Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation
In this manuscript, we develop a mathematical model to describe the spreading of an epidemic disease in a human population. The emphasis in this work will be on the study of the propagation of the coronavirus disease (COVID-19). Various epidemiologically relevant assumptions will be imposed upon the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506502/ https://www.ncbi.nlm.nih.gov/pubmed/32982020 http://dx.doi.org/10.1016/j.apm.2020.08.082 |
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author | Rafiq, Muhammad Macías-Díaz, J.E. Raza, Ali Ahmed, Nauman |
author_facet | Rafiq, Muhammad Macías-Díaz, J.E. Raza, Ali Ahmed, Nauman |
author_sort | Rafiq, Muhammad |
collection | PubMed |
description | In this manuscript, we develop a mathematical model to describe the spreading of an epidemic disease in a human population. The emphasis in this work will be on the study of the propagation of the coronavirus disease (COVID-19). Various epidemiologically relevant assumptions will be imposed upon the problem, and a coupled system of first-order ordinary differential equations will be obtained. The model adopts the form of a nonlinear susceptible-exposed-infected-quarantined-recovered system, and we investigate it both analytically and numerically. Analytically, we obtain the equilibrium points in the presence and absence of the coronavirus. We also calculate the reproduction number and provide conditions that guarantee the local and global asymptotic stability of the equilibria. To that end, various tools from analysis will be employed, including Volterra-type Lyapunov functions, LaSalle’s invariance principle and the Routh–Hurwitz criterion. To simulate computationally the dynamics of propagation of the disease, we propose a nonstandard finite-difference scheme to approximate the solutions of the mathematical model. A thorough analysis of the discrete model is provided in this work, including the consistency and the stability analyses, along with the capability of the discrete model to preserve the equilibria of the continuous system. Among other interesting results, our numerical simulations confirm the stability properties of the equilibrium points. |
format | Online Article Text |
id | pubmed-7506502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75065022020-09-23 Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation Rafiq, Muhammad Macías-Díaz, J.E. Raza, Ali Ahmed, Nauman Appl Math Model Article In this manuscript, we develop a mathematical model to describe the spreading of an epidemic disease in a human population. The emphasis in this work will be on the study of the propagation of the coronavirus disease (COVID-19). Various epidemiologically relevant assumptions will be imposed upon the problem, and a coupled system of first-order ordinary differential equations will be obtained. The model adopts the form of a nonlinear susceptible-exposed-infected-quarantined-recovered system, and we investigate it both analytically and numerically. Analytically, we obtain the equilibrium points in the presence and absence of the coronavirus. We also calculate the reproduction number and provide conditions that guarantee the local and global asymptotic stability of the equilibria. To that end, various tools from analysis will be employed, including Volterra-type Lyapunov functions, LaSalle’s invariance principle and the Routh–Hurwitz criterion. To simulate computationally the dynamics of propagation of the disease, we propose a nonstandard finite-difference scheme to approximate the solutions of the mathematical model. A thorough analysis of the discrete model is provided in this work, including the consistency and the stability analyses, along with the capability of the discrete model to preserve the equilibria of the continuous system. Among other interesting results, our numerical simulations confirm the stability properties of the equilibrium points. Elsevier Inc. 2021-01 2020-09-22 /pmc/articles/PMC7506502/ /pubmed/32982020 http://dx.doi.org/10.1016/j.apm.2020.08.082 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Rafiq, Muhammad Macías-Díaz, J.E. Raza, Ali Ahmed, Nauman Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation |
title | Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation |
title_full | Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation |
title_fullStr | Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation |
title_full_unstemmed | Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation |
title_short | Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation |
title_sort | design of a nonlinear model for the propagation of covid-19 and its efficient nonstandard computational implementation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506502/ https://www.ncbi.nlm.nih.gov/pubmed/32982020 http://dx.doi.org/10.1016/j.apm.2020.08.082 |
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