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Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation

In this manuscript, we develop a mathematical model to describe the spreading of an epidemic disease in a human population. The emphasis in this work will be on the study of the propagation of the coronavirus disease (COVID-19). Various epidemiologically relevant assumptions will be imposed upon the...

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Detalles Bibliográficos
Autores principales: Rafiq, Muhammad, Macías-Díaz, J.E., Raza, Ali, Ahmed, Nauman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506502/
https://www.ncbi.nlm.nih.gov/pubmed/32982020
http://dx.doi.org/10.1016/j.apm.2020.08.082
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author Rafiq, Muhammad
Macías-Díaz, J.E.
Raza, Ali
Ahmed, Nauman
author_facet Rafiq, Muhammad
Macías-Díaz, J.E.
Raza, Ali
Ahmed, Nauman
author_sort Rafiq, Muhammad
collection PubMed
description In this manuscript, we develop a mathematical model to describe the spreading of an epidemic disease in a human population. The emphasis in this work will be on the study of the propagation of the coronavirus disease (COVID-19). Various epidemiologically relevant assumptions will be imposed upon the problem, and a coupled system of first-order ordinary differential equations will be obtained. The model adopts the form of a nonlinear susceptible-exposed-infected-quarantined-recovered system, and we investigate it both analytically and numerically. Analytically, we obtain the equilibrium points in the presence and absence of the coronavirus. We also calculate the reproduction number and provide conditions that guarantee the local and global asymptotic stability of the equilibria. To that end, various tools from analysis will be employed, including Volterra-type Lyapunov functions, LaSalle’s invariance principle and the Routh–Hurwitz criterion. To simulate computationally the dynamics of propagation of the disease, we propose a nonstandard finite-difference scheme to approximate the solutions of the mathematical model. A thorough analysis of the discrete model is provided in this work, including the consistency and the stability analyses, along with the capability of the discrete model to preserve the equilibria of the continuous system. Among other interesting results, our numerical simulations confirm the stability properties of the equilibrium points.
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spelling pubmed-75065022020-09-23 Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation Rafiq, Muhammad Macías-Díaz, J.E. Raza, Ali Ahmed, Nauman Appl Math Model Article In this manuscript, we develop a mathematical model to describe the spreading of an epidemic disease in a human population. The emphasis in this work will be on the study of the propagation of the coronavirus disease (COVID-19). Various epidemiologically relevant assumptions will be imposed upon the problem, and a coupled system of first-order ordinary differential equations will be obtained. The model adopts the form of a nonlinear susceptible-exposed-infected-quarantined-recovered system, and we investigate it both analytically and numerically. Analytically, we obtain the equilibrium points in the presence and absence of the coronavirus. We also calculate the reproduction number and provide conditions that guarantee the local and global asymptotic stability of the equilibria. To that end, various tools from analysis will be employed, including Volterra-type Lyapunov functions, LaSalle’s invariance principle and the Routh–Hurwitz criterion. To simulate computationally the dynamics of propagation of the disease, we propose a nonstandard finite-difference scheme to approximate the solutions of the mathematical model. A thorough analysis of the discrete model is provided in this work, including the consistency and the stability analyses, along with the capability of the discrete model to preserve the equilibria of the continuous system. Among other interesting results, our numerical simulations confirm the stability properties of the equilibrium points. Elsevier Inc. 2021-01 2020-09-22 /pmc/articles/PMC7506502/ /pubmed/32982020 http://dx.doi.org/10.1016/j.apm.2020.08.082 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rafiq, Muhammad
Macías-Díaz, J.E.
Raza, Ali
Ahmed, Nauman
Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation
title Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation
title_full Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation
title_fullStr Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation
title_full_unstemmed Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation
title_short Design of a nonlinear model for the propagation of COVID-19 and its efficient nonstandard computational implementation
title_sort design of a nonlinear model for the propagation of covid-19 and its efficient nonstandard computational implementation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506502/
https://www.ncbi.nlm.nih.gov/pubmed/32982020
http://dx.doi.org/10.1016/j.apm.2020.08.082
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