A predictable conserved DNA base composition signature defines human core DNA replication origins

DNA replication initiates from multiple genomic locations called replication origins. In metazoa, DNA sequence elements involved in origin specification remain elusive. Here, we examine pluripotent, primary, differentiating, and immortalized human cells, and demonstrate that a class of origins, term...

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Detalles Bibliográficos
Autores principales: Akerman, Ildem, Kasaai, Bahar, Bazarova, Alina, Sang, Pau Biak, Peiffer, Isabelle, Artufel, Marie, Derelle, Romain, Smith, Gabrielle, Rodriguez-Martinez, Marta, Romano, Manuela, Kinet, Sandrina, Tino, Peter, Theillet, Charles, Taylor, Naomi, Ballester, Benoit, Méchali, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506530/
https://www.ncbi.nlm.nih.gov/pubmed/32958757
http://dx.doi.org/10.1038/s41467-020-18527-0

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