The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution

The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at cod...

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Detalles Bibliográficos
Autores principales: Ballhausen, Alexej, Przybilla, Moritz Jakob, Jendrusch, Michael, Haupt, Saskia, Pfaffendorf, Elisabeth, Seidler, Florian, Witt, Johannes, Hernandez Sanchez, Alejandro, Urban, Katharina, Draxlbauer, Markus, Krausert, Sonja, Ahadova, Aysel, Kalteis, Martin Simon, Pfuderer, Pauline L., Heid, Daniel, Stichel, Damian, Gebert, Johannes, Bonsack, Maria, Schott, Sarah, Bläker, Hendrik, Seppälä, Toni, Mecklin, Jukka-Pekka, Ten Broeke, Sanne, Nielsen, Maartje, Heuveline, Vincent, Krzykalla, Julia, Benner, Axel, Riemer, Angelika Beate, von Knebel Doeberitz, Magnus, Kloor, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506541/
https://www.ncbi.nlm.nih.gov/pubmed/32958755
http://dx.doi.org/10.1038/s41467-020-18514-5

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