GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of G(s) and G(q/11)

Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH-secreting pituitary tumors over-expressing the orphan G-protein coupled receptor, GPR101. The role of GPR101 in GH secretion remains o...

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Detalles Bibliográficos
Autores principales: Abboud, Dayana, Daly, Adrian F., Dupuis, Nadine, Bahri, Mohamed Ali, Inoue, Asuka, Chevigné, Andy, Ectors, Fabien, Plenevaux, Alain, Pirotte, Bernard, Beckers, Albert, Hanson, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506554/
https://www.ncbi.nlm.nih.gov/pubmed/32958754
http://dx.doi.org/10.1038/s41467-020-18500-x

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