Cargando…

Phenotypic and Genetic Characterization of Lower LDL Cholesterol and Increased Type 2 Diabetes Risk in the UK Biobank

Although hyperlipidemia is traditionally considered a risk factor for type 2 diabetes (T2D), evidence has emerged from statin trials and candidate gene investigations suggesting that lower LDL cholesterol (LDL-C) increases T2D risk. We thus sought to more comprehensively examine the phenotypic and g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klimentidis, Yann C., Arora, Amit, Newell, Michelle, Zhou, Jin, Ordovas, Jose M., Renquist, Benjamin J., Wood, Alexis C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506834/ https://www.ncbi.nlm.nih.gov/pubmed/32493714 http://dx.doi.org/10.2337/db19-1134

Ejemplares similares

Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles
por: Noordam, Raymond, et al.
Publicado: (2021)

Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study
por: Hidalgo, Bertha, et al.
Publicado: (2014)

Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
por: Axton, Elizabeth R, et al.
Publicado: (2019)

Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease
por: Emdin, Connor A., et al.
Publicado: (2017)

Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent
por: Haslam, Danielle E, et al.
Publicado: (2021)

MicroRNA Dysregulation in Diabetic Ischemic Heart Failure Patients
por: Greco, Simona, et al.
Publicado: (2012)

Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
por: Yaghootkar, Hanieh, et al.
Publicado: (2014)

Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus
por: Alfaifi, Mohammed, et al.
Publicado: (2021)

GATA6 Mutations Cause a Broad Phenotypic Spectrum of Diabetes From Pancreatic Agenesis to Adult-Onset Diabetes Without Exocrine Insufficiency
por: De Franco, Elisa, et al.
Publicado: (2013)

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
por: Karabegović, Irma, et al.
Publicado: (2022)

MicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes
por: Kurtz, C. Lisa, et al.
Publicado: (2014)

Pathways Targeted by Antidiabetes Drugs Are Enriched for Multiple Genes Associated With Type 2 Diabetes Risk
por: Segrè, Ayellet V., et al.
Publicado: (2015)

FTO Genotype, Vitamin D Status, and Weight Gain During Childhood
por: Lourenço, Barbara H., et al.
Publicado: (2014)

Identification of Cross-Species Shared Transcriptional Networks of Diabetic Nephropathy in Human and Mouse Glomeruli
por: Hodgin, Jeffrey B., et al.
Publicado: (2013)

DNA methylation changes and improved sleep quality in adults with obstructive sleep apnea and diabetes
por: Bigini, Evelyn G, et al.
Publicado: (2019)

Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
por: Qi, Qibin, et al.
Publicado: (2017)

TXNIP DNA methylation is associated with glycemic control over 28 years in type 1 diabetes: findings from the Pittsburgh Epidemiology of Diabetes Complications (EDC) study
por: Miller, Rachel G, et al.
Publicado: (2023)

Metabolite Profiles of Diabetes Incidence and Intervention Response in the Diabetes Prevention Program
por: Walford, Geoffrey A., et al.
Publicado: (2016)

Is Type 2 Diabetes Causally Associated With Cancer Risk? Evidence From a Two-Sample Mendelian Randomization Study
por: Yuan, Shuai, et al.
Publicado: (2020)

Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors
por: Merino, Jordi, et al.
Publicado: (2020)

A Polygenic Score for Type 2 Diabetes Risk Is Associated With Both the Acute and Sustained Response to Sulfonylureas
por: Li, Josephine H., et al.
Publicado: (2021)

Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
por: Aikens, Rachael C., et al.
Publicado: (2017)

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants
por: Wood, Andrew R., et al.
Publicado: (2017)

Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies
por: Qi, Qibin, et al.
Publicado: (2012)

Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials
por: Papandonatos, George D., et al.
Publicado: (2015)

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition(1)(2)(3)
por: Di Giovanni, Valeria, et al.
Publicado: (2016)

Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men
por: Pimentel, Grégory, et al.
Publicado: (2018)

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children(1)(2)(3)
por: Lee, Sun Eun, et al.
Publicado: (2017)

Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System–Related Oligosaccharides
por: Pimentel, Grégory, et al.
Publicado: (2020)

Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome
por: Zhu, Jing, et al.
Publicado: (2021)

Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores
por: Lindqvist, Helen M, et al.
Publicado: (2020)

DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm
por: Adams, Joselyn M, et al.
Publicado: (2022)

Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians
por: Thearle, Marie S., et al.
Publicado: (2012)

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes
por: Ferreira, Ricardo C., et al.
Publicado: (2014)

Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data
por: Johnson, Matthew E, et al.
Publicado: (2014)

Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection
por: Vassy, Jason L., et al.
Publicado: (2014)

Genetic Loci and Physiologic Pathways Involved in Gestational Diabetes Mellitus Implicated Through Clustering
por: Powe, Camille E., et al.
Publicado: (2021)

Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus
por: Powe, Camille E., et al.
Publicado: (2018)

Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth
por: Scholtens, Denise M., et al.
Publicado: (2016)

PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid
por: Morieri, Mario Luca, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_82gi3ioglfc4g95lk5no082i6b