Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway

[Image: see text] Angucyclines are a structurally diverse class of actinobacterial natural products defined by their varied polycyclic ring systems, which display a wide range of biological activities. We recently discovered lugdunomycin (1), a highly rearranged polyketide antibiotic derived from th...

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Detalles Bibliográficos
Autores principales: Xiao, Xiansha, Elsayed, Somayah S., Wu, Changsheng, van der Heul, Helga U., Metsä-Ketelä, Mikko, Du, Chao, Prota, Andrea E., Chen, Chun-Chi, Liu, Weidong, Guo, Rey-Ting, Abrahams, Jan Pieter, van Wezel, Gilles P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506943/
https://www.ncbi.nlm.nih.gov/pubmed/32840360
http://dx.doi.org/10.1021/acschembio.0c00564

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