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Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles

OBJECTIVE: Nickel oxide nanoparticles (NiONPs) are representative metal oxide NPs and are categorized as an insoluble nickel compound. Our previous studies suggested that NiONPs have more pulmonary toxicity than micron‐sized NiO because they may dissolve slowly and produce many more Ni ions. We conf...

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Autores principales: Nishi, Ken‐ichiro, Kadoya, Chikara, Ogami, Akira, Oyabu, Takako, Morimoto, Yasuo, Ueno, Susumu, Myojo, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506993/
https://www.ncbi.nlm.nih.gov/pubmed/32959980
http://dx.doi.org/10.1002/1348-9585.12162
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author Nishi, Ken‐ichiro
Kadoya, Chikara
Ogami, Akira
Oyabu, Takako
Morimoto, Yasuo
Ueno, Susumu
Myojo, Toshihiko
author_facet Nishi, Ken‐ichiro
Kadoya, Chikara
Ogami, Akira
Oyabu, Takako
Morimoto, Yasuo
Ueno, Susumu
Myojo, Toshihiko
author_sort Nishi, Ken‐ichiro
collection PubMed
description OBJECTIVE: Nickel oxide nanoparticles (NiONPs) are representative metal oxide NPs and are categorized as an insoluble nickel compound. Our previous studies suggested that NiONPs have more pulmonary toxicity than micron‐sized NiO because they may dissolve slowly and produce many more Ni ions. We confirmed the hypothesis that the slow dissolution of NiONPs induces a change in inflammatory response over time. METHOD: We reanalyzed our previous data on intratracheally instilled NiONP to rats and focused on Ni retention in the lungs and the lung weight ratio for each rat to the mean of control rat lungs. We also measured the solubility of NiONPs and micron‐sized NiO samples by means of an artificial lysosomal fluid (ALF, pH 4.5). RESULTS: The in vivo test of instilled NiONPs resulted in the biomarkers reaching their peak values at 1 week or 1 month, and not at 3 days, after instillation. We found that as the NiO mass in the lung increased, the lung weight ratios tended to increase. The relationships shifted to more toxic at 3 days to 1 month (P < .01). Compared to the dissolution of NiONPs in the ALF that took roughly 1 week, the dissolution of NiONPs in vivo was take about 1 month or more. CONCLUSION: When intratracheally instilled NiONPs dissolve slowly in the phagolysosomes of alveolar macrophages (AM), the resulting Ni ions cause the AM to transform into foamy cells at 1 month, and the inflammatory response persists even at 3 months after instillation.
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spelling pubmed-75069932020-09-28 Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles Nishi, Ken‐ichiro Kadoya, Chikara Ogami, Akira Oyabu, Takako Morimoto, Yasuo Ueno, Susumu Myojo, Toshihiko J Occup Health Original Articles OBJECTIVE: Nickel oxide nanoparticles (NiONPs) are representative metal oxide NPs and are categorized as an insoluble nickel compound. Our previous studies suggested that NiONPs have more pulmonary toxicity than micron‐sized NiO because they may dissolve slowly and produce many more Ni ions. We confirmed the hypothesis that the slow dissolution of NiONPs induces a change in inflammatory response over time. METHOD: We reanalyzed our previous data on intratracheally instilled NiONP to rats and focused on Ni retention in the lungs and the lung weight ratio for each rat to the mean of control rat lungs. We also measured the solubility of NiONPs and micron‐sized NiO samples by means of an artificial lysosomal fluid (ALF, pH 4.5). RESULTS: The in vivo test of instilled NiONPs resulted in the biomarkers reaching their peak values at 1 week or 1 month, and not at 3 days, after instillation. We found that as the NiO mass in the lung increased, the lung weight ratios tended to increase. The relationships shifted to more toxic at 3 days to 1 month (P < .01). Compared to the dissolution of NiONPs in the ALF that took roughly 1 week, the dissolution of NiONPs in vivo was take about 1 month or more. CONCLUSION: When intratracheally instilled NiONPs dissolve slowly in the phagolysosomes of alveolar macrophages (AM), the resulting Ni ions cause the AM to transform into foamy cells at 1 month, and the inflammatory response persists even at 3 months after instillation. John Wiley and Sons Inc. 2020-09-22 /pmc/articles/PMC7506993/ /pubmed/32959980 http://dx.doi.org/10.1002/1348-9585.12162 Text en © 2020 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Nishi, Ken‐ichiro
Kadoya, Chikara
Ogami, Akira
Oyabu, Takako
Morimoto, Yasuo
Ueno, Susumu
Myojo, Toshihiko
Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles
title Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles
title_full Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles
title_fullStr Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles
title_full_unstemmed Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles
title_short Changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles
title_sort changes over time in pulmonary inflammatory response in rat lungs after intratracheal instillation of nickel oxide nanoparticles
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506993/
https://www.ncbi.nlm.nih.gov/pubmed/32959980
http://dx.doi.org/10.1002/1348-9585.12162
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