A two‐dimensional multiwell cell culture method for the production of CYP3A4‐expressing hepatocyte‐like cells from HepaRG cells

Cytochrome P450 enzymes (CYP) function in drug metabolism in the liver. To evaluate numerous drug candidates, a high‐content screening (HCS) system with hepatocyte‐like cells (HLCs) that can replace adult human hepatocytes is required. Human hepatocellular carcinoma HepaRG is the only cell line capa...

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Detalles Bibliográficos
Autores principales: Ooeda, Keiko, Kubiura‐Ichimaru, Musashi, Tsuji, Saori, Okuyama, Shota, Yamashita, Mao, Mine, Akari, Kawamura, Fumihiko, Ueyama, Takafumi, Tada, Masako
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507088/
https://www.ncbi.nlm.nih.gov/pubmed/32955797
http://dx.doi.org/10.1002/prp2.652

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