Cargando…

Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors

We aimed at identifying the developmental stage at which leukemic cells of pediatric T‐ALLs are arrested and at defining leukemogenic mechanisms based on ATAC‐Seq. Chromatin accessibility maps of seven developmental stages of human healthy T cells revealed progressive chromatin condensation during T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Erarslan‐Uysal, Büşra, Kunz, Joachim B, Rausch, Tobias, Richter‐Pechańska, Paulina, van Belzen, Ianthe AEM, Frismantas, Viktoras, Bornhauser, Beat, Ordoñez‐Rueada, Diana, Paulsen, Malte, Benes, Vladimir, Stanulla, Martin, Schrappe, Martin, Cario, Gunnar, Escherich, Gabriele, Bakharevich, Kseniya, Kirschner‐Schwabe, Renate, Eckert, Cornelia, Loukanov, Tsvetomir, Gorenflo, Matthias, Waszak, Sebastian M, Bourquin, Jean‐Pierre, Muckenthaler, Martina U, Korbel, Jan O, Kulozik, Andreas E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507092/ https://www.ncbi.nlm.nih.gov/pubmed/32755029 http://dx.doi.org/10.15252/emmm.202012104

Ejemplares similares

PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia
por: Richter‐Pechańska, Paulina, et al.
Publicado: (2018)

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution
por: Richter-Pechańska, Paulina, et al.
Publicado: (2022)

P333: SUBCLONAL AND CLONAL VARIANTS IN TP53 AND KRAS COMBINED WITH POOR TREATMENT RESPONSE IDENTIFY A SUBGROUP OF ULTRA-HIGH-RISK PATIENTS OF PEDIATRIC T-LYMPHOBLASTIC LEUKEMIA (T-ALL)
por: Kempter, Tamara, et al.
Publicado: (2023)

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia
por: Richter-Pechańska, P, et al.
Publicado: (2017)

Hypoplastic Left Heart Syndrome – Unresolved Issues
por: Arnold, Raoul Roman, et al.
Publicado: (2014)

Right Ventricular Failure and Pathobiology in Patients with Congenital Heart Disease – Implications for Long-Term Follow-Up
por: Köhler, Doreen, et al.
Publicado: (2013)

Impact of hybrid procedure on pulmonary arterial dimensions and right ventricular load after biventricular repair
por: Uhl, Sebastian, et al.
Publicado: (2023)

Intracardiac Extension of Wilms Tumor: A Case of a 2.5-Year-Old Girl Presenting with Upper Venous Congestion Caused by Tumor Growth into the Right Cardiac Ventricle
por: Imle, Roland, et al.
Publicado: (2019)

Surgical Treatment Following Stent Angioplasty for High-Risk Neonates With Critical Coarctation of the Aorta
por: Grieshaber, Philippe, et al.
Publicado: (2022)

Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
por: Shochat, Chen, et al.
Publicado: (2011)

Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias
por: Shochat, Chen, et al.
Publicado: (2011)

P350: DAB1 EXPRESSION DRIVES PROLIFERATION AND METABOLIC ACTIVITY IN T-ALL AND INTERFERES WITH T-CELL-SPECIFIC PATHWAYS
por: Spleis, Valentina, et al.
Publicado: (2023)

The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL–BFM 2000 protocol can be separated from FBXW7 loss of function
por: Kox, C, et al.
Publicado: (2010)

Model-driven survival prediction after congenital heart surgery
por: Zürn, Christoph, et al.
Publicado: (2023)

MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB
por: Cordas dos Santos, David M., et al.
Publicado: (2018)

Repurposing anthelmintic agents to eradicate resistant leukemia
por: Mezzatesta, Caterina, et al.
Publicado: (2020)

Immune biomarkers for predicting response to adoptive cell transfer as cancer treatment
por: van Belzen, Ianthe A. E. M., et al.
Publicado: (2018)

P322: DECIPHERING THE UNDERLYING MOLECULAR COMPLEXITY OF THE IKZF1PLUS SIGNATURE
por: Lühmann, Jonathan, et al.
Publicado: (2023)

Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group
por: Junk, Stefanie V., et al.
Publicado: (2023)

Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population
por: Schnakenberg, Eckart, et al.
Publicado: (2005)

Functional analysis of structural variants in single cells using Strand-seq
por: Jeong, Hyobin, et al.
Publicado: (2022)

Tumor necrosis factor and lymphotoxin-alpha genetic polymorphisms and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study of patients treated with BFM therapy
por: Stanulla, Martin, et al.
Publicado: (2001)

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction
por: Muckenthaler, Lena, et al.
Publicado: (2022)

Frequency and prognostic impact of ZEB2 H1038 and Q1072 mutations in childhood B-other acute lymphoblastic leukemia
por: Zaliova, Marketa, et al.
Publicado: (2020)

Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis
por: Vogiatzi, Fotini, et al.
Publicado: (2022)

Deferasirox-induced robust and dose-dependent reversal of anemia in a patient with variants in the TRIB2 and ABCB6 genes
por: Stomper, Julia, et al.
Publicado: (2022)

Molecular complete remission following combination treatment of daratumumab and venetoclax in an adolescent with relapsed mixed phenotype acute leukemia
por: Stanulla, Martin, et al.
Publicado: (2023)

Structural variant detection in cancer genomes: computational challenges and perspectives for precision oncology
por: van Belzen, Ianthe A. E. M., et al.
Publicado: (2021)

A script to highlight hydrophobicity and charge on protein surfaces
por: Hagemans, Dominique, et al.
Publicado: (2015)

Hypersensitivity Reactions to Native E. coli L-asparaginase in Children With Acute Lymphoblastic Leukemia Treated in Trial ALL-BFM 2000: Impact of Treatment Schedule and Type of Glucocorticoid in Induction
por: Möricke, Anja, et al.
Publicado: (2023)

Frequency and prognostic impact of PAX5 p.P80R in pediatric acute lymphoblastic leukemia patients treated on an AIEOP‐BFM acute lymphoblastic leukemia protocol
por: Jung, Mareike, et al.
Publicado: (2020)

BCR-ABL1-like acute lymphoblastic leukemia in childhood and targeted therapy
por: Cario, Gunnar, et al.
Publicado: (2020)

Genetic polymorphisms of the lymphotoxin alpha gene are associated with increased risk for lethal infections during induction therapy for childhood acute leukemia: a case-control study
por: Kidas, Ekaterini, et al.
Publicado: (2009)

The Clinical Utility of Optical Genome Mapping for the Assessment of Genomic Aberrations in Acute Lymphoblastic Leukemia
por: Lühmann, Jonathan Lukas, et al.
Publicado: (2021)

RNA degradation compromises the reliability of microRNA expression profiling
por: Ibberson, David, et al.
Publicado: (2009)

Butler enables rapid cloud-based analysis of thousands of human genomes
por: Yakneen, Sergei, et al.
Publicado: (2020)

Publisher Correction: Butler enables rapid cloud-based analysis of thousands of human genomes
por: Yakneen, Sergei, et al.
Publicado: (2020)

Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes
por: Yakneen, Sergei, et al.
Publicado: (2023)

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support
por: Boutter, Jeannette, et al.
Publicado: (2014)

CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia
por: Palmi, Chiara, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rd7ogs2qaqib0oj63h879lhlpj