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Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children

BACKGROUND/OBJECTIVES: Several exposures during pregnancy are associated with offspring body mass index (BMI). The objective of this study was to evaluate whether third trimester antibiotic use and vaginal infections are associated with BMI in preschool children. SUBJECTS/METHODS: The study populati...

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Autores principales: Isaevska, Elena, Popovic, Maja, Pizzi, Costanza, Fiano, Valentina, Rusconi, Franca, Merletti, Franco, Richiardi, Lorenzo, Maule, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507215/
https://www.ncbi.nlm.nih.gov/pubmed/32174046
http://dx.doi.org/10.1111/ijpo.12632
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author Isaevska, Elena
Popovic, Maja
Pizzi, Costanza
Fiano, Valentina
Rusconi, Franca
Merletti, Franco
Richiardi, Lorenzo
Maule, Milena
author_facet Isaevska, Elena
Popovic, Maja
Pizzi, Costanza
Fiano, Valentina
Rusconi, Franca
Merletti, Franco
Richiardi, Lorenzo
Maule, Milena
author_sort Isaevska, Elena
collection PubMed
description BACKGROUND/OBJECTIVES: Several exposures during pregnancy are associated with offspring body mass index (BMI). The objective of this study was to evaluate whether third trimester antibiotic use and vaginal infections are associated with BMI in preschool children. SUBJECTS/METHODS: The study population included singletons from the NINFEA birth cohort with available anthropometric measurements at the age of 4 (3151 born with vaginal and 1111 born with caesarean delivery). Self‐reported use of antibiotics and the presence of vaginal infection in the third trimester were analysed in association with the child's BMI, classified into three categories: thinness, normal and overweight/obesity, using both the International Obesity Task Force (IOTF) and the World Health Organization (WHO) recommended cut‐offs. RESULTS: Maternal vaginal infections in the third trimester of pregnancy were associated with higher relative risk ratios (RRR) for overweight/obesity at age of four in children delivered vaginally: 1.92 (95% confidence interval [CI]: 1.37 to 2.70). This association appeared stronger for children born to women with pre‐pregnancy BMI >25 kg/m(2) (RRR: 4.78; 95% CI 2.45 to 9.35), and was robust when different obesity cut‐offs were used. The results regarding third trimester antibiotic use in vaginal deliveries were less conclusive (RRRs for overweight/obesity: 1.43 (0.92 to 2.21) and 1.11 (0.57 to 2.20), for the IOTF and WHO cut‐offs, respectively). Third trimester vaginal infections were not associated with BMI in children delivered by caesarean section. CONCLUSIONS: Maternal third trimester vaginal infections are associated with an increased overweight/obesity risk in children born by vaginal delivery, and especially in children of mothers with pre‐pregnancy overweight/obesity.
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spelling pubmed-75072152020-09-28 Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children Isaevska, Elena Popovic, Maja Pizzi, Costanza Fiano, Valentina Rusconi, Franca Merletti, Franco Richiardi, Lorenzo Maule, Milena Pediatr Obes Original Research BACKGROUND/OBJECTIVES: Several exposures during pregnancy are associated with offspring body mass index (BMI). The objective of this study was to evaluate whether third trimester antibiotic use and vaginal infections are associated with BMI in preschool children. SUBJECTS/METHODS: The study population included singletons from the NINFEA birth cohort with available anthropometric measurements at the age of 4 (3151 born with vaginal and 1111 born with caesarean delivery). Self‐reported use of antibiotics and the presence of vaginal infection in the third trimester were analysed in association with the child's BMI, classified into three categories: thinness, normal and overweight/obesity, using both the International Obesity Task Force (IOTF) and the World Health Organization (WHO) recommended cut‐offs. RESULTS: Maternal vaginal infections in the third trimester of pregnancy were associated with higher relative risk ratios (RRR) for overweight/obesity at age of four in children delivered vaginally: 1.92 (95% confidence interval [CI]: 1.37 to 2.70). This association appeared stronger for children born to women with pre‐pregnancy BMI >25 kg/m(2) (RRR: 4.78; 95% CI 2.45 to 9.35), and was robust when different obesity cut‐offs were used. The results regarding third trimester antibiotic use in vaginal deliveries were less conclusive (RRRs for overweight/obesity: 1.43 (0.92 to 2.21) and 1.11 (0.57 to 2.20), for the IOTF and WHO cut‐offs, respectively). Third trimester vaginal infections were not associated with BMI in children delivered by caesarean section. CONCLUSIONS: Maternal third trimester vaginal infections are associated with an increased overweight/obesity risk in children born by vaginal delivery, and especially in children of mothers with pre‐pregnancy overweight/obesity. John Wiley & Sons, Inc. 2020-03-16 2020-08 /pmc/articles/PMC7507215/ /pubmed/32174046 http://dx.doi.org/10.1111/ijpo.12632 Text en © 2020 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Isaevska, Elena
Popovic, Maja
Pizzi, Costanza
Fiano, Valentina
Rusconi, Franca
Merletti, Franco
Richiardi, Lorenzo
Maule, Milena
Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children
title Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children
title_full Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children
title_fullStr Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children
title_full_unstemmed Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children
title_short Maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children
title_sort maternal antibiotic use and vaginal infections in the third trimester of pregnancy and the risk of obesity in preschool children
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507215/
https://www.ncbi.nlm.nih.gov/pubmed/32174046
http://dx.doi.org/10.1111/ijpo.12632
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