The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis

BACKGROUND: Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it is not clear how formate induces pyrimidine synthesis. METHODS: Here we combin...

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Detalles Bibliográficos
Autores principales: Tait-Mulder, Jacqueline, Hodge, Kelly, Sumpton, David, Zanivan, Sara, Vazquez, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507243/
https://www.ncbi.nlm.nih.gov/pubmed/32974014
http://dx.doi.org/10.1186/s40170-020-00228-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507243/
https://www.ncbi.nlm.nih.gov/pubmed/32974014
http://dx.doi.org/10.1186/s40170-020-00228-3

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