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The conversion of formate into purines stimulates mTORC1 leading to CAD-dependent activation of pyrimidine synthesis
BACKGROUND: Mitochondrial serine catabolism to formate induces a metabolic switch to a hypermetabolic state with high rates of glycolysis, purine synthesis and pyrimidine synthesis. While formate is a purine precursor, it is not clear how formate induces pyrimidine synthesis. METHODS: Here we combin...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507243/ https://www.ncbi.nlm.nih.gov/pubmed/32974014 http://dx.doi.org/10.1186/s40170-020-00228-3 |