C1orf109L binding DHX9 promotes DNA damage depended on the R‐loop accumulation and enhances camptothecin chemosensitivity

OBJECTIVES: R‐loop is a three‐stranded nucleic acid structure of RNA/DNA hybrid, which occurs naturally during transcription, and more R‐loop accumulation can trigger serious DNA damage. There has been increasing attention to the issue of R‐loop accumulation acted as a target for cancer therapy. How...

Descripción completa

Detalles Bibliográficos
Autores principales: Dou, Peng, Li, Yiqun, Sun, Haoxiu, Xie, Wanqiu, Zhang, Xiaoqing, Zhang, Xiaohan, Zhang, Dandan, Qiao, Shupei, Ci, Yanpeng, Nie, Huan, Han, Fang, Li, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507383/
https://www.ncbi.nlm.nih.gov/pubmed/32761833
http://dx.doi.org/10.1111/cpr.12875

Ejemplares similares

Ejemplares similares