The NRF2 stimulating agent, tin protoporphyrin, activates protective cytokine pathways in healthy human subjects and in patients with chronic kidney disease

BACKGROUND: Tin protoporphyrin (SnPP), a heme oxygenase 1 (HO‐1) inhibitor, triggers adaptive tissue responses that confer potent protection against acute renal‐ and extra‐renal tissue injuries. This effect is mediated, in part, via SnPP‐induced activation of the cytoprotective Nrf2 pathway. However...

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Detalles Bibliográficos
Autores principales: Zager, Richard A., Johnson, Ali C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507518/
https://www.ncbi.nlm.nih.gov/pubmed/32940965
http://dx.doi.org/10.14814/phy2.14566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507518/
https://www.ncbi.nlm.nih.gov/pubmed/32940965
http://dx.doi.org/10.14814/phy2.14566

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