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Pre‐Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring

INTRODUCTION: Adolescence is a period of heightened susceptibility to anxiety disorders. Probiotic supplementation had a positive impact on reducing anxiety. The maternal microbiome plays an important role in child health outcomes and in the establishment of the offspring microbiome. Few studies hav...

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Autores principales: Niu, Yunxia, Liang, Shan, Wang, Tao, Hu, Xu, Li, Wei, Wu, Xiaoli, Jin, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507564/
https://www.ncbi.nlm.nih.gov/pubmed/32681606
http://dx.doi.org/10.1002/brb3.1714
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author Niu, Yunxia
Liang, Shan
Wang, Tao
Hu, Xu
Li, Wei
Wu, Xiaoli
Jin, Feng
author_facet Niu, Yunxia
Liang, Shan
Wang, Tao
Hu, Xu
Li, Wei
Wu, Xiaoli
Jin, Feng
author_sort Niu, Yunxia
collection PubMed
description INTRODUCTION: Adolescence is a period of heightened susceptibility to anxiety disorders. Probiotic supplementation had a positive impact on reducing anxiety. The maternal microbiome plays an important role in child health outcomes and in the establishment of the offspring microbiome. Few studies have investigated the impact of gestational probiotic supplementation on the offspring's anxiety. METHODS: The present study examined the impact of prenatal Lactobacillus helveticus NS8 supplementation (LAC) on Sprague Dawley rat offspring's anxiety‐like behavior. The behaviors tested in the present study include the elevated plus maze (EPM), the open field test (OFT), and prepulse inhibition (PPI). Analyses of variance were utilized. RESULTS: (a) The performance of LAC adolescent rats in the EPM was similar to that in the OFT, both of which reflect that LAC caused an antianxiety effect in adolescent offspring rats and the antianxiety effect without sex differences; (b) LAC did not change performance in PPI and did not change the sex and age differences in PPI; and c. LAC decreased the body mass of rat offspring. CONCLUSION: Lactobacillus helveticus NS8 supplementation during gestation might have a moderate antianxiety effect in both males and females (especially adolescents) and be helpful for avoiding excessive body mass.
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spelling pubmed-75075642020-09-29 Pre‐Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring Niu, Yunxia Liang, Shan Wang, Tao Hu, Xu Li, Wei Wu, Xiaoli Jin, Feng Brain Behav Original Research INTRODUCTION: Adolescence is a period of heightened susceptibility to anxiety disorders. Probiotic supplementation had a positive impact on reducing anxiety. The maternal microbiome plays an important role in child health outcomes and in the establishment of the offspring microbiome. Few studies have investigated the impact of gestational probiotic supplementation on the offspring's anxiety. METHODS: The present study examined the impact of prenatal Lactobacillus helveticus NS8 supplementation (LAC) on Sprague Dawley rat offspring's anxiety‐like behavior. The behaviors tested in the present study include the elevated plus maze (EPM), the open field test (OFT), and prepulse inhibition (PPI). Analyses of variance were utilized. RESULTS: (a) The performance of LAC adolescent rats in the EPM was similar to that in the OFT, both of which reflect that LAC caused an antianxiety effect in adolescent offspring rats and the antianxiety effect without sex differences; (b) LAC did not change performance in PPI and did not change the sex and age differences in PPI; and c. LAC decreased the body mass of rat offspring. CONCLUSION: Lactobacillus helveticus NS8 supplementation during gestation might have a moderate antianxiety effect in both males and females (especially adolescents) and be helpful for avoiding excessive body mass. John Wiley and Sons Inc. 2020-07-17 /pmc/articles/PMC7507564/ /pubmed/32681606 http://dx.doi.org/10.1002/brb3.1714 Text en © 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Niu, Yunxia
Liang, Shan
Wang, Tao
Hu, Xu
Li, Wei
Wu, Xiaoli
Jin, Feng
Pre‐Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring
title Pre‐Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring
title_full Pre‐Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring
title_fullStr Pre‐Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring
title_full_unstemmed Pre‐Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring
title_short Pre‐Gestational intake of Lactobacillus helveticus NS8 has anxiolytic effects in adolescent Sprague Dawley offspring
title_sort pre‐gestational intake of lactobacillus helveticus ns8 has anxiolytic effects in adolescent sprague dawley offspring
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507564/
https://www.ncbi.nlm.nih.gov/pubmed/32681606
http://dx.doi.org/10.1002/brb3.1714
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