A Structure-Based Mechanism for DNA Entry into the Cohesin Ring

Despite key roles in sister chromatid cohesion and chromosome organization, the mechanism by which cohesin rings are loaded onto DNA is still unknown. Here we combine biochemical approaches and cryoelectron microscopy (cryo-EM) to visualize a cohesin loading intermediate in which DNA is locked betwe...

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Detalles Bibliográficos
Autores principales: Higashi, Torahiko L., Eickhoff, Patrik, Sousa, Joana S., Locke, Julia, Nans, Andrea, Flynn, Helen R., Snijders, Ambrosius P., Papageorgiou, George, O’Reilly, Nicola, Chen, Zhuo A., O’Reilly, Francis J., Rappsilber, Juri, Costa, Alessandro, Uhlmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507959/
https://www.ncbi.nlm.nih.gov/pubmed/32755595
http://dx.doi.org/10.1016/j.molcel.2020.07.013

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