BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity and cell survival. Dysregulation of these systems can lead to conflicts between the transcription and replication machinery, causing DNA damage and cell death. BRD4 allows...

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Detalles Bibliográficos
Autores principales: Edwards, Drake S., Maganti, Rohin, Tanksley, Jarred P., Luo, Jie, Park, James J.H., Balkanska-Sinclair, Elena, Ling, Jinjie, Floyd, Scott R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507985/
https://www.ncbi.nlm.nih.gov/pubmed/32966794
http://dx.doi.org/10.1016/j.celrep.2020.108166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507985/
https://www.ncbi.nlm.nih.gov/pubmed/32966794
http://dx.doi.org/10.1016/j.celrep.2020.108166

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