Cargando…

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity and cell survival. Dysregulation of these systems can lead to conflicts between the transcription and replication machinery, causing DNA damage and cell death. BRD4 allows...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edwards, Drake S., Maganti, Rohin, Tanksley, Jarred P., Luo, Jie, Park, James J.H., Balkanska-Sinclair, Elena, Ling, Jinjie, Floyd, Scott R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Author(s). 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507985/ https://www.ncbi.nlm.nih.gov/pubmed/32966794 http://dx.doi.org/10.1016/j.celrep.2020.108166

Ejemplares similares

BRD4: a general regulator of transcription elongation
por: Altendorfer, Elisabeth, et al.
Publicado: (2022)

BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
por: Lam, Fred C., et al.
Publicado: (2020)

GLTSCR1 Negatively Regulates BRD4‐Dependent Transcription Elongation and Inhibits CRC Metastasis
por: Han, Fengyan, et al.
Publicado: (2019)

Consequences and Resolution of Transcription–Replication Conflicts
por: Lalonde, Maxime, et al.
Publicado: (2021)

Co-directional replication-transcription conflicts lead to replication restart
por: Merrikh, Houra, et al.
Publicado: (2011)

Topoisomerase I prevents transcription-replication conflicts at transcription termination sites
por: Liu, Yaqun, et al.
Publicado: (2020)

The Elongation Complex Components BRD4 and MLLT3/AF9 Are Transcriptional Coactivators of Nuclear Retinoid Receptors
por: Flajollet, Sébastien, et al.
Publicado: (2013)

The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability
por: Santos-Pereira, José M., et al.
Publicado: (2013)

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription–replication conflicts
por: Herrera-Moyano, Emilia, et al.
Publicado: (2014)

DDX17 helicase promotes resolution of R-loop-mediated transcription–replication conflicts in human cells
por: Boleslavska, Barbora, et al.
Publicado: (2022)

BRD4 inhibitors block telomere elongation
por: Wang, Steven, et al.
Publicado: (2017)

Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes
por: Micco, Raffaella Di, et al.
Publicado: (2014)

A novel mechanism for the prevention of transcription replication conflicts
por: Canal, Berta, et al.
Publicado: (2018)

The enigmatic role of Mfd in replication-transcription conflicts in bacteria
por: Ragheb, Mark, et al.
Publicado: (2019)

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
por: Chang, Emily Yun-Chia, et al.
Publicado: (2019)

The roles of replication-transcription conflict in mutagenesis and evolution of genome organization
por: Schroeder, Jeremy W., et al.
Publicado: (2020)

Coordinating transcription and replication to mitigate their conflicts in early Drosophila embryos
por: Cho, Chun-Yi, et al.
Publicado: (2022)

Small molecule targeting of transcription-replication conflict for selective chemotherapy
por: Gu, Long, et al.
Publicado: (2023)

Transcription elongation factor Brd4-P-TEFb accelerates intestinal differentiation-associated SLC2A5 gene expression
por: Inamochi, Yuko, et al.
Publicado: (2016)

Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids
por: Stoy, Henriette, et al.
Publicado: (2023)

BRD4 and Cancer: going beyond transcriptional regulation
por: Donati, Benedetta, et al.
Publicado: (2018)

Positive supercoiling favors transcription elongation through lac repressor-mediated DNA loops
por: Xu, Wenxuan, et al.
Publicado: (2022)

Transcription elongation regulator 1 (TCERG1) regulates competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral replication
por: Coiras, Mayte, et al.
Publicado: (2013)

Topological stress is responsible for the detrimental outcomes of head-on replication-transcription conflicts
por: Lang, Kevin S., et al.
Publicado: (2021)

Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation
por: Ijaz, Talha, et al.
Publicado: (2017)

Control of eukaryotic transcription elongation
por: Winston, Fred
Publicado: (2001)

Elongator: Transcriptional or translational regulator?
por: Glatt, Sebastian, et al.
Publicado: (2012)

Regulation of Transcription Elongation and Termination
por: Washburn, Robert S., et al.
Publicado: (2015)

Mechanism of assembly of an elongation-competent SARS-CoV-2 replication transcription complex
por: Klein, Misha, et al.
Publicado: (2023)

BRD4 jump-starts transcription after mitotic silencing
por: Voigt, Philipp, et al.
Publicado: (2011)

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
por: Behera, Vivek, et al.
Publicado: (2019)

BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation
por: Shivji, Mahmud K.K., et al.
Publicado: (2018)

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability
por: Zatreanu, Diana, et al.
Publicado: (2019)

TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells
por: Scaramuzza, Shaun, et al.
Publicado: (2023)

The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
por: Bayona-Feliu, Aleix, et al.
Publicado: (2023)

FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells
por: Xu, Weiwei, et al.
Publicado: (2023)

Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers
por: Patel, Parasvi S, et al.
Publicado: (2023)

The Role of Replication Clamp-Loader Protein HolC of Escherichia coli in Overcoming Replication/Transcription Conflicts
por: Cooper, Deani L., et al.
Publicado: (2021)

Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions
por: Park, Kiwon, et al.
Publicado: (2021)

Spt4 Promotes Pol I Processivity and Transcription Elongation
por: Huffines, Abigail K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_f3ulqqjjcnko90betpfs76n8dl