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Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation?
PURPOSE: To study the correlation between thyroid eye disease (TED) with type-2 diabetes mellitus. METHODS: A cross-sectional cohort study was conducted from Jan 2018 to Dec 2018, in patients presenting with thyroid eye disease to orbit and oculoplasty clinic of a tertiary eye care hospital. A total...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508111/ https://www.ncbi.nlm.nih.gov/pubmed/32461446 http://dx.doi.org/10.4103/ijo.IJO_1443_19 |
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author | Ramamurthy, Lakshmi B Rangarajan, Viji Srirao, Neha Malini, Bindu Bansal, Renu Yuvarajan, Kavitha |
author_facet | Ramamurthy, Lakshmi B Rangarajan, Viji Srirao, Neha Malini, Bindu Bansal, Renu Yuvarajan, Kavitha |
author_sort | Ramamurthy, Lakshmi B |
collection | PubMed |
description | PURPOSE: To study the correlation between thyroid eye disease (TED) with type-2 diabetes mellitus. METHODS: A cross-sectional cohort study was conducted from Jan 2018 to Dec 2018, in patients presenting with thyroid eye disease to orbit and oculoplasty clinic of a tertiary eye care hospital. A total of 105 patients were included in the study. All patients underwent detailed ophthalmic evaluation and thyroid eye disease workup. Patients were categorized into mild, moderate, and severe/sight-threatening TED based on EUGOGO classification. Systemic history of diabetes was noted. RBS was done in all patients. RESULTS: Mild disease was noted 61 patients of which 11 were diabetics, moderate in 26 patients (8 diabetics), and severe disease in 18 patients (14 diabetics). All patients were treated accordingly. Among the TED patients, the percentage of diabetic patients was noted to be in increasing order toward the severity spectrum of TED. The prevalence of severe TED was found to be much higher in diabetic patients accounting upto 77.77% of 18 patients. A statistically significant correlation was noted (P = 0.014) between severe TED and type-2 diabetes mellitus. In addition, early onset of thyroid eye disease was noted in type-2 diabetes patients. Even though female preponderance was noted, severe TED was more in men (66.6%). CONCLUSION: An autoimmune etiology for the association of thyroid and type-1diabetes has been well established. This study shows that type-2 diabetic patients can have more severity in the clinical presentation of TED. Therefore, the presence of type-2 DM in patients with TED can be a predictive factor for onset, progression, and severity of disease. Hence, a high concern of interest among treating ophthalmologists and endocrinologists regarding this entity would help in early prediction and decreased morbidity among such patients. |
format | Online Article Text |
id | pubmed-7508111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-75081112020-10-02 Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? Ramamurthy, Lakshmi B Rangarajan, Viji Srirao, Neha Malini, Bindu Bansal, Renu Yuvarajan, Kavitha Indian J Ophthalmol Original Article PURPOSE: To study the correlation between thyroid eye disease (TED) with type-2 diabetes mellitus. METHODS: A cross-sectional cohort study was conducted from Jan 2018 to Dec 2018, in patients presenting with thyroid eye disease to orbit and oculoplasty clinic of a tertiary eye care hospital. A total of 105 patients were included in the study. All patients underwent detailed ophthalmic evaluation and thyroid eye disease workup. Patients were categorized into mild, moderate, and severe/sight-threatening TED based on EUGOGO classification. Systemic history of diabetes was noted. RBS was done in all patients. RESULTS: Mild disease was noted 61 patients of which 11 were diabetics, moderate in 26 patients (8 diabetics), and severe disease in 18 patients (14 diabetics). All patients were treated accordingly. Among the TED patients, the percentage of diabetic patients was noted to be in increasing order toward the severity spectrum of TED. The prevalence of severe TED was found to be much higher in diabetic patients accounting upto 77.77% of 18 patients. A statistically significant correlation was noted (P = 0.014) between severe TED and type-2 diabetes mellitus. In addition, early onset of thyroid eye disease was noted in type-2 diabetes patients. Even though female preponderance was noted, severe TED was more in men (66.6%). CONCLUSION: An autoimmune etiology for the association of thyroid and type-1diabetes has been well established. This study shows that type-2 diabetic patients can have more severity in the clinical presentation of TED. Therefore, the presence of type-2 DM in patients with TED can be a predictive factor for onset, progression, and severity of disease. Hence, a high concern of interest among treating ophthalmologists and endocrinologists regarding this entity would help in early prediction and decreased morbidity among such patients. Wolters Kluwer - Medknow 2020-06 2020-05-25 /pmc/articles/PMC7508111/ /pubmed/32461446 http://dx.doi.org/10.4103/ijo.IJO_1443_19 Text en Copyright: © 2020 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Ramamurthy, Lakshmi B Rangarajan, Viji Srirao, Neha Malini, Bindu Bansal, Renu Yuvarajan, Kavitha Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
title | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
title_full | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
title_fullStr | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
title_full_unstemmed | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
title_short | Severity of thyroid eye disease and type-2 diabetes mellitus: Is there a correlation? |
title_sort | severity of thyroid eye disease and type-2 diabetes mellitus: is there a correlation? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508111/ https://www.ncbi.nlm.nih.gov/pubmed/32461446 http://dx.doi.org/10.4103/ijo.IJO_1443_19 |
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