COVID-19 confirmed patients with negative antibodies results

BACKGROUND: A new coronavirus disease 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of patients may have difficulty in generating IgM or IgG antibodies against SARS-CoV-2, and little attention has been paid to them. CASE PRESENTATIONS: We pr...

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Autores principales: Wang, Jian, Chen, Chong, Li, Qilin, Cai, Pengcheng, Wang, Zheng, Wang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508244/
https://www.ncbi.nlm.nih.gov/pubmed/32962655
http://dx.doi.org/10.1186/s12879-020-05419-3
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author Wang, Jian
Chen, Chong
Li, Qilin
Cai, Pengcheng
Wang, Zheng
Wang, Lin
author_facet Wang, Jian
Chen, Chong
Li, Qilin
Cai, Pengcheng
Wang, Zheng
Wang, Lin
author_sort Wang, Jian
collection PubMed
description BACKGROUND: A new coronavirus disease 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of patients may have difficulty in generating IgM or IgG antibodies against SARS-CoV-2, and little attention has been paid to them. CASE PRESENTATIONS: We present two cases of confirmed COVID-19 patients and characterize their initial symptoms, chest CT results, medication, and laboratory test results in detail (including RT-PCR, IgM/ IgG, cytokine and blood cell counts). CONCLUSION: Both of patients with confirmed COVID-19 pneumonia failed to produce either IgM or IgG even 40 to 50 days after their symptoms onset. This work provides evidence demonstrating that at least a small proportion of patients may have difficulty in rapidly gaining immunity against SARS-CoV-2.
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spelling pubmed-75082442020-09-23 COVID-19 confirmed patients with negative antibodies results Wang, Jian Chen, Chong Li, Qilin Cai, Pengcheng Wang, Zheng Wang, Lin BMC Infect Dis Case Report BACKGROUND: A new coronavirus disease 2019 (COVID-19) has escalated to a pandemic since its first outbreak in Wuhan, China. A small proportion of patients may have difficulty in generating IgM or IgG antibodies against SARS-CoV-2, and little attention has been paid to them. CASE PRESENTATIONS: We present two cases of confirmed COVID-19 patients and characterize their initial symptoms, chest CT results, medication, and laboratory test results in detail (including RT-PCR, IgM/ IgG, cytokine and blood cell counts). CONCLUSION: Both of patients with confirmed COVID-19 pneumonia failed to produce either IgM or IgG even 40 to 50 days after their symptoms onset. This work provides evidence demonstrating that at least a small proportion of patients may have difficulty in rapidly gaining immunity against SARS-CoV-2. BioMed Central 2020-09-22 /pmc/articles/PMC7508244/ /pubmed/32962655 http://dx.doi.org/10.1186/s12879-020-05419-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Wang, Jian
Chen, Chong
Li, Qilin
Cai, Pengcheng
Wang, Zheng
Wang, Lin
COVID-19 confirmed patients with negative antibodies results
title COVID-19 confirmed patients with negative antibodies results
title_full COVID-19 confirmed patients with negative antibodies results
title_fullStr COVID-19 confirmed patients with negative antibodies results
title_full_unstemmed COVID-19 confirmed patients with negative antibodies results
title_short COVID-19 confirmed patients with negative antibodies results
title_sort covid-19 confirmed patients with negative antibodies results
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508244/
https://www.ncbi.nlm.nih.gov/pubmed/32962655
http://dx.doi.org/10.1186/s12879-020-05419-3
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