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Pathophysiology of Aortic Aneurysms: Insights from Animal Studies

Aortic aneurysms are defined as dilations of the aorta greater than 50 percent. Currently, the only effective treatment for aortic aneurysms is surgical repair, which is recommended only to those that meet criteria. There is no available pharmaceutical therapy to slow aneurysm growth and thus preven...

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Detalles Bibliográficos
Autores principales: Khoury, Mitri K, Stranz, Amelia R, Liu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508467/
https://www.ncbi.nlm.nih.gov/pubmed/32968712
http://dx.doi.org/10.26502/fccm.92920146
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author Khoury, Mitri K
Stranz, Amelia R
Liu, Bo
author_facet Khoury, Mitri K
Stranz, Amelia R
Liu, Bo
author_sort Khoury, Mitri K
collection PubMed
description Aortic aneurysms are defined as dilations of the aorta greater than 50 percent. Currently, the only effective treatment for aortic aneurysms is surgical repair, which is recommended only to those that meet criteria. There is no available pharmaceutical therapy to slow aneurysm growth and thus prevent lethal rupture. The development of a number of murine models has allowed in depth studies of various cellular and extracellular components of aneurysm pathophysiology. The identification of key therapeutic targets has resulted in several clinical trials evaluating pharmaceutical candidates to treat aneurysm progression. In this review, we focus on providing recent updates on developments in murine models of aortic aneurysm. In addition, we discuss recent studies of the various cellular and extracellular components of the aorta along with the abutting aortic structures that contribute to aneurysm development and progression.
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spelling pubmed-75084672020-09-22 Pathophysiology of Aortic Aneurysms: Insights from Animal Studies Khoury, Mitri K Stranz, Amelia R Liu, Bo Cardiol Cardiovasc Med Article Aortic aneurysms are defined as dilations of the aorta greater than 50 percent. Currently, the only effective treatment for aortic aneurysms is surgical repair, which is recommended only to those that meet criteria. There is no available pharmaceutical therapy to slow aneurysm growth and thus prevent lethal rupture. The development of a number of murine models has allowed in depth studies of various cellular and extracellular components of aneurysm pathophysiology. The identification of key therapeutic targets has resulted in several clinical trials evaluating pharmaceutical candidates to treat aneurysm progression. In this review, we focus on providing recent updates on developments in murine models of aortic aneurysm. In addition, we discuss recent studies of the various cellular and extracellular components of the aorta along with the abutting aortic structures that contribute to aneurysm development and progression. 2020-08-31 2020-08 /pmc/articles/PMC7508467/ /pubmed/32968712 http://dx.doi.org/10.26502/fccm.92920146 Text en http://creativecommons.org/licenses/by/4.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license 4.0
spellingShingle Article
Khoury, Mitri K
Stranz, Amelia R
Liu, Bo
Pathophysiology of Aortic Aneurysms: Insights from Animal Studies
title Pathophysiology of Aortic Aneurysms: Insights from Animal Studies
title_full Pathophysiology of Aortic Aneurysms: Insights from Animal Studies
title_fullStr Pathophysiology of Aortic Aneurysms: Insights from Animal Studies
title_full_unstemmed Pathophysiology of Aortic Aneurysms: Insights from Animal Studies
title_short Pathophysiology of Aortic Aneurysms: Insights from Animal Studies
title_sort pathophysiology of aortic aneurysms: insights from animal studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508467/
https://www.ncbi.nlm.nih.gov/pubmed/32968712
http://dx.doi.org/10.26502/fccm.92920146
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