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HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis
We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried dispr...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508592/ https://www.ncbi.nlm.nih.gov/pubmed/32718966 http://dx.doi.org/10.1128/AAC.00782-20 |
| _version_ | 1783585449368879104 |
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| author | Loiseau, Chloé Brites, Daniela Reinhard, Miriam Zürcher, Kathrin Borrell, Sonia Ballif, Marie Fenner, Lukas Cox, Helen Rutaihwa, Liliana K. Wilkinson, Robert J. Yotebieng, Marcel Carter, E. Jane Abimiku, Alash'le Marcy, Olivier Gotuzzo, Eduardo Avihingsanon, Anchalee Zetola, Nicola Doulla, Basra Böttger, Erik C. Egger, Matthias Gagneux, Sebastien |
| author_facet | Loiseau, Chloé Brites, Daniela Reinhard, Miriam Zürcher, Kathrin Borrell, Sonia Ballif, Marie Fenner, Lukas Cox, Helen Rutaihwa, Liliana K. Wilkinson, Robert J. Yotebieng, Marcel Carter, E. Jane Abimiku, Alash'le Marcy, Olivier Gotuzzo, Eduardo Avihingsanon, Anchalee Zetola, Nicola Doulla, Basra Böttger, Erik C. Egger, Matthias Gagneux, Sebastien |
| author_sort | Loiseau, Chloé |
| collection | PubMed |
| description | We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. |
| format | Online Article Text |
| id | pubmed-7508592 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75085922020-10-02 HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis Loiseau, Chloé Brites, Daniela Reinhard, Miriam Zürcher, Kathrin Borrell, Sonia Ballif, Marie Fenner, Lukas Cox, Helen Rutaihwa, Liliana K. Wilkinson, Robert J. Yotebieng, Marcel Carter, E. Jane Abimiku, Alash'le Marcy, Olivier Gotuzzo, Eduardo Avihingsanon, Anchalee Zetola, Nicola Doulla, Basra Böttger, Erik C. Egger, Matthias Gagneux, Sebastien Antimicrob Agents Chemother Epidemiology and Surveillance We analyzed 312 drug-resistant genomes of Mycobacterium tuberculosis isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant M. tuberculosis strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low-fitness rpoB variants can thrive in the context of reduced host immunity. American Society for Microbiology 2020-09-21 /pmc/articles/PMC7508592/ /pubmed/32718966 http://dx.doi.org/10.1128/AAC.00782-20 Text en Copyright © 2020 Loiseau et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Epidemiology and Surveillance Loiseau, Chloé Brites, Daniela Reinhard, Miriam Zürcher, Kathrin Borrell, Sonia Ballif, Marie Fenner, Lukas Cox, Helen Rutaihwa, Liliana K. Wilkinson, Robert J. Yotebieng, Marcel Carter, E. Jane Abimiku, Alash'le Marcy, Olivier Gotuzzo, Eduardo Avihingsanon, Anchalee Zetola, Nicola Doulla, Basra Böttger, Erik C. Egger, Matthias Gagneux, Sebastien HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis |
| title | HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis |
| title_full | HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis |
| title_fullStr | HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis |
| title_full_unstemmed | HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis |
| title_short | HIV Coinfection Is Associated with Low-Fitness rpoB Variants in Rifampicin-Resistant Mycobacterium tuberculosis |
| title_sort | hiv coinfection is associated with low-fitness rpob variants in rifampicin-resistant mycobacterium tuberculosis |
| topic | Epidemiology and Surveillance |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508592/ https://www.ncbi.nlm.nih.gov/pubmed/32718966 http://dx.doi.org/10.1128/AAC.00782-20 |
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