PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018)

• PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation. • Unfavourable intermediate/high risk and bulky local disease are most likely to benefit. • Functional MRI imaging is used to select patients for different types of dose escalation. • HDR brachytherapy or f...

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Autores principales: Syndikus, Isabel, Cruickshank, Clare, Staffurth, John, Tree, Alison, Henry, Ann, Naismith, Olivia, Mayles, Helen, Snelson, Nicola, Hassan, Shama, Brown, Stephanie, Porta, Nuria, Griffin, Clare, Hall, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508714/
https://www.ncbi.nlm.nih.gov/pubmed/32995575
http://dx.doi.org/10.1016/j.ctro.2020.08.003
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author Syndikus, Isabel
Cruickshank, Clare
Staffurth, John
Tree, Alison
Henry, Ann
Naismith, Olivia
Mayles, Helen
Snelson, Nicola
Hassan, Shama
Brown, Stephanie
Porta, Nuria
Griffin, Clare
Hall, Emma
author_facet Syndikus, Isabel
Cruickshank, Clare
Staffurth, John
Tree, Alison
Henry, Ann
Naismith, Olivia
Mayles, Helen
Snelson, Nicola
Hassan, Shama
Brown, Stephanie
Porta, Nuria
Griffin, Clare
Hall, Emma
author_sort Syndikus, Isabel
collection PubMed
description • PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation. • Unfavourable intermediate/high risk and bulky local disease are most likely to benefit. • Functional MRI imaging is used to select patients for different types of dose escalation. • HDR brachytherapy or focal dose escalation with IMRT are used as options. • Training and support is provided to reduce variations of contouring and radiotherapy planning. • The trial is recruiting patients in 38 radiotherapy centres through the UK.
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spelling pubmed-75087142020-09-28 PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018) Syndikus, Isabel Cruickshank, Clare Staffurth, John Tree, Alison Henry, Ann Naismith, Olivia Mayles, Helen Snelson, Nicola Hassan, Shama Brown, Stephanie Porta, Nuria Griffin, Clare Hall, Emma Clin Transl Radiat Oncol Technical Note • PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation. • Unfavourable intermediate/high risk and bulky local disease are most likely to benefit. • Functional MRI imaging is used to select patients for different types of dose escalation. • HDR brachytherapy or focal dose escalation with IMRT are used as options. • Training and support is provided to reduce variations of contouring and radiotherapy planning. • The trial is recruiting patients in 38 radiotherapy centres through the UK. Elsevier 2020-09-01 /pmc/articles/PMC7508714/ /pubmed/32995575 http://dx.doi.org/10.1016/j.ctro.2020.08.003 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Technical Note
Syndikus, Isabel
Cruickshank, Clare
Staffurth, John
Tree, Alison
Henry, Ann
Naismith, Olivia
Mayles, Helen
Snelson, Nicola
Hassan, Shama
Brown, Stephanie
Porta, Nuria
Griffin, Clare
Hall, Emma
PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018)
title PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018)
title_full PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018)
title_fullStr PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018)
title_full_unstemmed PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018)
title_short PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018)
title_sort pivotalboost: a phase iii randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (cruk/16/018)
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508714/
https://www.ncbi.nlm.nih.gov/pubmed/32995575
http://dx.doi.org/10.1016/j.ctro.2020.08.003
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