Cargando…
Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population
Aims: We aimed to examine the associations of four extracranial artery indicators with cerebral small vessel disease (CSVD) and its total burden. Methods: A total of 904 individuals aged 55–65 years old were included from the Taizhou Imaging Study. CSVD markers, including lacunes (LAC), white matter...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Atherosclerosis Society
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508727/ https://www.ncbi.nlm.nih.gov/pubmed/32037371 http://dx.doi.org/10.5551/jat.52530 |
_version_ | 1783585471709839360 |
---|---|
author | Zhang, Kexun Jiang, Yanfeng Wang, Yingzhe Suo, Chen Xu, Kelin Zhu, Zhen Zhu, Chengkai Zhao, Genming Jin, Li Ye, Weimin Cui, Mei Chen, Xingdong |
author_facet | Zhang, Kexun Jiang, Yanfeng Wang, Yingzhe Suo, Chen Xu, Kelin Zhu, Zhen Zhu, Chengkai Zhao, Genming Jin, Li Ye, Weimin Cui, Mei Chen, Xingdong |
author_sort | Zhang, Kexun |
collection | PubMed |
description | Aims: We aimed to examine the associations of four extracranial artery indicators with cerebral small vessel disease (CSVD) and its total burden. Methods: A total of 904 individuals aged 55–65 years old were included from the Taizhou Imaging Study. CSVD markers, including lacunes (LAC), white matter hyperintensities (WMH), cerebral microbleeds (CMB), and perivascular spaces (PVS), were rated based on brain magnetic resonance imaging. We also measured extracranial artery indices, including the brachial-ankle pulse wave velocity (baPWV), the ankle-brachial index, the carotid intima-media thickness (IMT), and carotid plaque. Linear and binary logistic regressions were adopted to test the associations among these four artery indicators and each CSVD marker when appropriate. Additionally, ordinal and multinomial logistic regressions were performed to assess the relationships between artery indicators and total CSVD score (range from 0–4 points). Results: A total of 443 (49.0%) participants were found to have at least one of the CSVD markers, including 172 (19.0%) with WMH, 184 (20.4%) with LAC, 147 (16.3%) with CMB, and 226 (25.0%) with PVS. Increased baPWV was significantly associated with each CSVD marker, increasing carotid IMT was associated with LAC and PVS, and the presence of carotid plaque was associated with WMH volume and PVS. Moreover, per SD increment of baPWV (odds ratio [OR]: 1.29, 95% confidence interval [CI]: 1.11–1.50) and the presence of carotid plaque (OR: 1.42, 95% CI: 1.05–1.92) were significantly associated with greater total CSVD scores. Conclusion: Increased baPWV and the presence of carotid plaque appear to be associated with total CSVD burden in rural regions in China. |
format | Online Article Text |
id | pubmed-7508727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Japan Atherosclerosis Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-75087272020-09-28 Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population Zhang, Kexun Jiang, Yanfeng Wang, Yingzhe Suo, Chen Xu, Kelin Zhu, Zhen Zhu, Chengkai Zhao, Genming Jin, Li Ye, Weimin Cui, Mei Chen, Xingdong J Atheroscler Thromb Original Article Aims: We aimed to examine the associations of four extracranial artery indicators with cerebral small vessel disease (CSVD) and its total burden. Methods: A total of 904 individuals aged 55–65 years old were included from the Taizhou Imaging Study. CSVD markers, including lacunes (LAC), white matter hyperintensities (WMH), cerebral microbleeds (CMB), and perivascular spaces (PVS), were rated based on brain magnetic resonance imaging. We also measured extracranial artery indices, including the brachial-ankle pulse wave velocity (baPWV), the ankle-brachial index, the carotid intima-media thickness (IMT), and carotid plaque. Linear and binary logistic regressions were adopted to test the associations among these four artery indicators and each CSVD marker when appropriate. Additionally, ordinal and multinomial logistic regressions were performed to assess the relationships between artery indicators and total CSVD score (range from 0–4 points). Results: A total of 443 (49.0%) participants were found to have at least one of the CSVD markers, including 172 (19.0%) with WMH, 184 (20.4%) with LAC, 147 (16.3%) with CMB, and 226 (25.0%) with PVS. Increased baPWV was significantly associated with each CSVD marker, increasing carotid IMT was associated with LAC and PVS, and the presence of carotid plaque was associated with WMH volume and PVS. Moreover, per SD increment of baPWV (odds ratio [OR]: 1.29, 95% confidence interval [CI]: 1.11–1.50) and the presence of carotid plaque (OR: 1.42, 95% CI: 1.05–1.92) were significantly associated with greater total CSVD scores. Conclusion: Increased baPWV and the presence of carotid plaque appear to be associated with total CSVD burden in rural regions in China. Japan Atherosclerosis Society 2020-09-01 /pmc/articles/PMC7508727/ /pubmed/32037371 http://dx.doi.org/10.5551/jat.52530 Text en 2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Original Article Zhang, Kexun Jiang, Yanfeng Wang, Yingzhe Suo, Chen Xu, Kelin Zhu, Zhen Zhu, Chengkai Zhao, Genming Jin, Li Ye, Weimin Cui, Mei Chen, Xingdong Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population |
title | Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population |
title_full | Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population |
title_fullStr | Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population |
title_full_unstemmed | Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population |
title_short | Associations of Arterial Stiffness and Carotid Atherosclerosis with Cerebral Small Vessel Disease in a Rural Community-Based Population |
title_sort | associations of arterial stiffness and carotid atherosclerosis with cerebral small vessel disease in a rural community-based population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508727/ https://www.ncbi.nlm.nih.gov/pubmed/32037371 http://dx.doi.org/10.5551/jat.52530 |
work_keys_str_mv | AT zhangkexun associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT jiangyanfeng associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT wangyingzhe associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT suochen associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT xukelin associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT zhuzhen associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT zhuchengkai associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT zhaogenming associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT jinli associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT yeweimin associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT cuimei associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation AT chenxingdong associationsofarterialstiffnessandcarotidatherosclerosiswithcerebralsmallvesseldiseaseinaruralcommunitybasedpopulation |