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Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined region...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508833/ https://www.ncbi.nlm.nih.gov/pubmed/32963231 http://dx.doi.org/10.1038/s41467-020-18367-y |
| _version_ | 1783585483221106688 |
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| author | Hofer, Edith Roshchupkin, Gennady V. Adams, Hieab H. H. Knol, Maria J. Lin, Honghuang Li, Shuo Zare, Habil Ahmad, Shahzad Armstrong, Nicola J. Satizabal, Claudia L. Bernard, Manon Bis, Joshua C. Gillespie, Nathan A. Luciano, Michelle Mishra, Aniket Scholz, Markus Teumer, Alexander Xia, Rui Jian, Xueqiu Mosley, Thomas H. Saba, Yasaman Pirpamer, Lukas Seiler, Stephan Becker, James T. Carmichael, Owen Rotter, Jerome I. Psaty, Bruce M. Lopez, Oscar L. Amin, Najaf van der Lee, Sven J. Yang, Qiong Himali, Jayandra J. Maillard, Pauline Beiser, Alexa S. DeCarli, Charles Karama, Sherif Lewis, Lindsay Harris, Mat Bastin, Mark E. Deary, Ian J. Veronica Witte, A. Beyer, Frauke Loeffler, Markus Mather, Karen A. Schofield, Peter R. Thalamuthu, Anbupalam Kwok, John B. Wright, Margaret J. Ames, David Trollor, Julian Jiang, Jiyang Brodaty, Henry Wen, Wei Vernooij, Meike W. Hofman, Albert Uitterlinden, André G. Niessen, Wiro J. Wittfeld, Katharina Bülow, Robin Völker, Uwe Pausova, Zdenka Bruce Pike, G. Maingault, Sophie Crivello, Fabrice Tzourio, Christophe Amouyel, Philippe Mazoyer, Bernard Neale, Michael C. Franz, Carol E. Lyons, Michael J. Panizzon, Matthew S. Andreassen, Ole A. Dale, Anders M. Logue, Mark Grasby, Katrina L. Jahanshad, Neda Painter, Jodie N. Colodro-Conde, Lucía Bralten, Janita Hibar, Derrek P. Lind, Penelope A. Pizzagalli, Fabrizio Stein, Jason L. Thompson, Paul M. Medland, Sarah E. Sachdev, Perminder S. Kremen, William S. Wardlaw, Joanna M. Villringer, Arno van Duijn, Cornelia M. Grabe, Hans J. Longstreth, William T. Fornage, Myriam Paus, Tomas Debette, Stephanie Arfan Ikram, M. Schmidt, Helena Schmidt, Reinhold Seshadri, Sudha |
| author_facet | Hofer, Edith Roshchupkin, Gennady V. Adams, Hieab H. H. Knol, Maria J. Lin, Honghuang Li, Shuo Zare, Habil Ahmad, Shahzad Armstrong, Nicola J. Satizabal, Claudia L. Bernard, Manon Bis, Joshua C. Gillespie, Nathan A. Luciano, Michelle Mishra, Aniket Scholz, Markus Teumer, Alexander Xia, Rui Jian, Xueqiu Mosley, Thomas H. Saba, Yasaman Pirpamer, Lukas Seiler, Stephan Becker, James T. Carmichael, Owen Rotter, Jerome I. Psaty, Bruce M. Lopez, Oscar L. Amin, Najaf van der Lee, Sven J. Yang, Qiong Himali, Jayandra J. Maillard, Pauline Beiser, Alexa S. DeCarli, Charles Karama, Sherif Lewis, Lindsay Harris, Mat Bastin, Mark E. Deary, Ian J. Veronica Witte, A. Beyer, Frauke Loeffler, Markus Mather, Karen A. Schofield, Peter R. Thalamuthu, Anbupalam Kwok, John B. Wright, Margaret J. Ames, David Trollor, Julian Jiang, Jiyang Brodaty, Henry Wen, Wei Vernooij, Meike W. Hofman, Albert Uitterlinden, André G. Niessen, Wiro J. Wittfeld, Katharina Bülow, Robin Völker, Uwe Pausova, Zdenka Bruce Pike, G. Maingault, Sophie Crivello, Fabrice Tzourio, Christophe Amouyel, Philippe Mazoyer, Bernard Neale, Michael C. Franz, Carol E. Lyons, Michael J. Panizzon, Matthew S. Andreassen, Ole A. Dale, Anders M. Logue, Mark Grasby, Katrina L. Jahanshad, Neda Painter, Jodie N. Colodro-Conde, Lucía Bralten, Janita Hibar, Derrek P. Lind, Penelope A. Pizzagalli, Fabrizio Stein, Jason L. Thompson, Paul M. Medland, Sarah E. Sachdev, Perminder S. Kremen, William S. Wardlaw, Joanna M. Villringer, Arno van Duijn, Cornelia M. Grabe, Hans J. Longstreth, William T. Fornage, Myriam Paus, Tomas Debette, Stephanie Arfan Ikram, M. Schmidt, Helena Schmidt, Reinhold Seshadri, Sudha |
| author_sort | Hofer, Edith |
| collection | PubMed |
| description | Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging. |
| format | Online Article Text |
| id | pubmed-7508833 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75088332020-10-08 Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults Hofer, Edith Roshchupkin, Gennady V. Adams, Hieab H. H. Knol, Maria J. Lin, Honghuang Li, Shuo Zare, Habil Ahmad, Shahzad Armstrong, Nicola J. Satizabal, Claudia L. Bernard, Manon Bis, Joshua C. Gillespie, Nathan A. Luciano, Michelle Mishra, Aniket Scholz, Markus Teumer, Alexander Xia, Rui Jian, Xueqiu Mosley, Thomas H. Saba, Yasaman Pirpamer, Lukas Seiler, Stephan Becker, James T. Carmichael, Owen Rotter, Jerome I. Psaty, Bruce M. Lopez, Oscar L. Amin, Najaf van der Lee, Sven J. Yang, Qiong Himali, Jayandra J. Maillard, Pauline Beiser, Alexa S. DeCarli, Charles Karama, Sherif Lewis, Lindsay Harris, Mat Bastin, Mark E. Deary, Ian J. Veronica Witte, A. Beyer, Frauke Loeffler, Markus Mather, Karen A. Schofield, Peter R. Thalamuthu, Anbupalam Kwok, John B. Wright, Margaret J. Ames, David Trollor, Julian Jiang, Jiyang Brodaty, Henry Wen, Wei Vernooij, Meike W. Hofman, Albert Uitterlinden, André G. Niessen, Wiro J. Wittfeld, Katharina Bülow, Robin Völker, Uwe Pausova, Zdenka Bruce Pike, G. Maingault, Sophie Crivello, Fabrice Tzourio, Christophe Amouyel, Philippe Mazoyer, Bernard Neale, Michael C. Franz, Carol E. Lyons, Michael J. Panizzon, Matthew S. Andreassen, Ole A. Dale, Anders M. Logue, Mark Grasby, Katrina L. Jahanshad, Neda Painter, Jodie N. Colodro-Conde, Lucía Bralten, Janita Hibar, Derrek P. Lind, Penelope A. Pizzagalli, Fabrizio Stein, Jason L. Thompson, Paul M. Medland, Sarah E. Sachdev, Perminder S. Kremen, William S. Wardlaw, Joanna M. Villringer, Arno van Duijn, Cornelia M. Grabe, Hans J. Longstreth, William T. Fornage, Myriam Paus, Tomas Debette, Stephanie Arfan Ikram, M. Schmidt, Helena Schmidt, Reinhold Seshadri, Sudha Nat Commun Article Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging. Nature Publishing Group UK 2020-09-22 /pmc/articles/PMC7508833/ /pubmed/32963231 http://dx.doi.org/10.1038/s41467-020-18367-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Hofer, Edith Roshchupkin, Gennady V. Adams, Hieab H. H. Knol, Maria J. Lin, Honghuang Li, Shuo Zare, Habil Ahmad, Shahzad Armstrong, Nicola J. Satizabal, Claudia L. Bernard, Manon Bis, Joshua C. Gillespie, Nathan A. Luciano, Michelle Mishra, Aniket Scholz, Markus Teumer, Alexander Xia, Rui Jian, Xueqiu Mosley, Thomas H. Saba, Yasaman Pirpamer, Lukas Seiler, Stephan Becker, James T. Carmichael, Owen Rotter, Jerome I. Psaty, Bruce M. Lopez, Oscar L. Amin, Najaf van der Lee, Sven J. Yang, Qiong Himali, Jayandra J. Maillard, Pauline Beiser, Alexa S. DeCarli, Charles Karama, Sherif Lewis, Lindsay Harris, Mat Bastin, Mark E. Deary, Ian J. Veronica Witte, A. Beyer, Frauke Loeffler, Markus Mather, Karen A. Schofield, Peter R. Thalamuthu, Anbupalam Kwok, John B. Wright, Margaret J. Ames, David Trollor, Julian Jiang, Jiyang Brodaty, Henry Wen, Wei Vernooij, Meike W. Hofman, Albert Uitterlinden, André G. Niessen, Wiro J. Wittfeld, Katharina Bülow, Robin Völker, Uwe Pausova, Zdenka Bruce Pike, G. Maingault, Sophie Crivello, Fabrice Tzourio, Christophe Amouyel, Philippe Mazoyer, Bernard Neale, Michael C. Franz, Carol E. Lyons, Michael J. Panizzon, Matthew S. Andreassen, Ole A. Dale, Anders M. Logue, Mark Grasby, Katrina L. Jahanshad, Neda Painter, Jodie N. Colodro-Conde, Lucía Bralten, Janita Hibar, Derrek P. Lind, Penelope A. Pizzagalli, Fabrizio Stein, Jason L. Thompson, Paul M. Medland, Sarah E. Sachdev, Perminder S. Kremen, William S. Wardlaw, Joanna M. Villringer, Arno van Duijn, Cornelia M. Grabe, Hans J. Longstreth, William T. Fornage, Myriam Paus, Tomas Debette, Stephanie Arfan Ikram, M. Schmidt, Helena Schmidt, Reinhold Seshadri, Sudha Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults |
| title | Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults |
| title_full | Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults |
| title_fullStr | Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults |
| title_full_unstemmed | Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults |
| title_short | Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults |
| title_sort | genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508833/ https://www.ncbi.nlm.nih.gov/pubmed/32963231 http://dx.doi.org/10.1038/s41467-020-18367-y |
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