Cargando…

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break

Genomic integrity is threatened by cytotoxic DNA double-strand breaks (DSBs), which must be resolved efficiently to prevent sequence loss, chromosomal rearrangements/translocations, or cell death. Polymerase μ (Polμ) participates in DSB repair via the nonhomologous end-joining (NHEJ) pathway, by fil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaminski, Andrea M., Pryor, John M., Ramsden, Dale A., Kunkel, Thomas A., Pedersen, Lars C., Bebenek, Katarzyna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508851/ https://www.ncbi.nlm.nih.gov/pubmed/32963245 http://dx.doi.org/10.1038/s41467-020-18506-5

Ejemplares similares

Time-lapse crystallography snapshots of a double-strand break repair polymerase in action
por: Jamsen, Joonas A., et al.
Publicado: (2017)

Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining
por: Kaminski, Andrea M., et al.
Publicado: (2022)

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu
por: Moon, Andrea F., et al.
Publicado: (2017)

Substrate-induced DNA strand misalignment during catalytic cycling by DNA polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2008)

Structure–Function Studies of DNA Polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2014)

Structural Insights into the Specificity of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass by Family X DNA Polymerases
por: Kaminski, Andrea M., et al.
Publicado: (2021)

Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase λ in human nuclear extracts
por: Zhou, Rui-Zhe, et al.
Publicado: (2008)

Involvement of DNA polymerase μ in the repair of a specific subset of DNA double-strand breaks in mammalian cells
por: Capp, Jean-Pascal, et al.
Publicado: (2007)

Altered Hematopoiesis in Mice Lacking DNA Polymerase μ Is Due to Inefficient Double-Strand Break Repair
por: Lucas, Daniel, et al.
Publicado: (2009)

Promiscuous mismatch extension by human DNA polymerase lambda
por: Picher, Angel J., et al.
Publicado: (2006)

Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase
por: Brissett, Nigel C., et al.
Publicado: (2013)

Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks
por: Kusumoto-Matsuo, Rika, et al.
Publicado: (2014)

Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system
por: Zhao, Bailin, et al.
Publicado: (2020)

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks
por: Caron, Marie-Christine, et al.
Publicado: (2019)

Scrunching During DNA Repair Synthesis
por: Garcia-Diaz, Miguel, et al.
Publicado: (2009)

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
por: Reid, Dylan A., et al.
Publicado: (2017)

The DNA polymerase λ is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells
por: Capp, Jean-Pascal, et al.
Publicado: (2006)

DNA polymerase θ-mediated repair of high LET radiation-induced complex DNA double-strand breaks
por: Yi, Geunil, et al.
Publicado: (2023)

Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks
por: Chakraborty, Anirban, et al.
Publicado: (2023)

Loop 1 modulates the fidelity of DNA polymerase λ
por: Bebenek, Katarzyna, et al.
Publicado: (2010)

The ubiquitin landscape at DNA double-strand breaks
por: Messick, Troy E., et al.
Publicado: (2009)

Nucleolar responses to DNA double-strand breaks
por: Larsen, Dorthe Helena, et al.
Publicado: (2016)

Repair of DNA Double-Strand Breaks in Heterochromatin
por: Watts, Felicity Z.
Publicado: (2016)

Physiological Roles of DNA Double-Strand Breaks
por: Khan, Farhaan A., et al.
Publicado: (2017)

Boon and Bane of DNA Double-Strand Breaks
por: Schubert, Ingo
Publicado: (2021)

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery
por: Noël, Georges, et al.
Publicado: (2003)

Plant organellar DNA polymerases repair double-stranded breaks by microhomology-mediated end-joining
por: García-Medel, Paola L, et al.
Publicado: (2019)

RNA polymerase II is recruited to DNA double-strand breaks for dilncRNA transcription in Drosophila
por: Böttcher, Romy, et al.
Publicado: (2021)

Arabidopsis DNA polymerase lambda mutant is mildly sensitive to DNA double strand breaks but defective in integration of a transgene
por: Furukawa, Tomoyuki, et al.
Publicado: (2015)

The Contribution of Alu Elements to Mutagenic DNA Double-Strand Break Repair
por: Morales, Maria E., et al.
Publicado: (2015)

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
por: Kalasova, Ilona, et al.
Publicado: (2020)

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila
por: Chan, Sze Ham, et al.
Publicado: (2010)

Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks
por: Burger, Kaspar, et al.
Publicado: (2019)

Dna2 initiates resection at clean DNA double-strand breaks
por: Paudyal, Sharad C., et al.
Publicado: (2017)

Quantification of DNA double‐strand breaks using Geant4‐DNA
por: Chatzipapas, Konstantinos P., et al.
Publicado: (2018)

DNA Double-Strand Break Repairs and Their Application in Plant DNA Integration
por: Shen, Hexi, et al.
Publicado: (2022)

DNA double-strand break end synapsis by DNA loop extrusion
por: Yang, Jin H., et al.
Publicado: (2023)

DNA double-strand break repair in Caenorhabditis elegans
por: Lemmens, Bennie B. L. G., et al.
Publicado: (2010)

DNA double-strand break signaling and human disorders
por: Bohgaki, Toshiyuki, et al.
Publicado: (2010)

Nampt is involved in DNA double-strand break repair
por: Zhu, Bingtao, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_9lpgi086mb8l3j9mk2f01ct9ri