IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration

Evidence points to an indispensable function of macrophages in tissue regeneration, yet the underlying molecular mechanisms remain elusive. Here we demonstrate a protective function for the IL-33-ST2 axis in bronchial epithelial repair, and implicate ST2 in myeloid cell differentiation. ST2 deficien...

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Detalles Bibliográficos
Autores principales: Dagher, Rania, Copenhaver, Alan M., Besnard, Valerie, Berlin, Aaron, Hamidi, Fatima, Maret, Marielle, Wang, Jingya, Qu, Xiaotao, Shrestha, Yashaswi, Wu, Jincheng, Gautier, Gregory, Raja, Rajiv, Aubier, Michel, Kolbeck, Roland, Humbles, Alison A., Pretolani, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508874/
https://www.ncbi.nlm.nih.gov/pubmed/32963227
http://dx.doi.org/10.1038/s41467-020-18466-w

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