Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells

An effective host immune system prevents the growth of most cancer cells. However, as intestinal nematodes are able to induce both immunotolerance and immunosuppression in the host, it is possible that their presence could allow co-occurring cancer cells to proliferate and metastasize. Our findings...

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Autores principales: Donskow-Łysoniewska, Katarzyna, Krawczak, Katarzyna, Machcińska, Maja, Brodaczewska, Klaudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508930/
https://www.ncbi.nlm.nih.gov/pubmed/32960348
http://dx.doi.org/10.1007/s00005-020-00594-2
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author Donskow-Łysoniewska, Katarzyna
Krawczak, Katarzyna
Machcińska, Maja
Brodaczewska, Klaudia
author_facet Donskow-Łysoniewska, Katarzyna
Krawczak, Katarzyna
Machcińska, Maja
Brodaczewska, Klaudia
author_sort Donskow-Łysoniewska, Katarzyna
collection PubMed
description An effective host immune system prevents the growth of most cancer cells. However, as intestinal nematodes are able to induce both immunotolerance and immunosuppression in the host, it is possible that their presence could allow co-occurring cancer cells to proliferate and metastasize. Our findings indicate that previous, subsequent or concurrent intestinal nematode infection affects the formation of lung metastatic nodules in mice experimentally infected with Heligmosomoides polygyrus. In addition, pre-infection with nematodes renders mice resistant to metastasis development in lungs, with the inoculated EL4 cancer cells being located mainly in mesenteric lymph nodes. The present paper discusses the nematode-induced mechanisms which may influence the metastatic process.
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spelling pubmed-75089302020-10-14 Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells Donskow-Łysoniewska, Katarzyna Krawczak, Katarzyna Machcińska, Maja Brodaczewska, Klaudia Arch Immunol Ther Exp (Warsz) Short Communication An effective host immune system prevents the growth of most cancer cells. However, as intestinal nematodes are able to induce both immunotolerance and immunosuppression in the host, it is possible that their presence could allow co-occurring cancer cells to proliferate and metastasize. Our findings indicate that previous, subsequent or concurrent intestinal nematode infection affects the formation of lung metastatic nodules in mice experimentally infected with Heligmosomoides polygyrus. In addition, pre-infection with nematodes renders mice resistant to metastasis development in lungs, with the inoculated EL4 cancer cells being located mainly in mesenteric lymph nodes. The present paper discusses the nematode-induced mechanisms which may influence the metastatic process. Springer International Publishing 2020-09-22 2020 /pmc/articles/PMC7508930/ /pubmed/32960348 http://dx.doi.org/10.1007/s00005-020-00594-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Donskow-Łysoniewska, Katarzyna
Krawczak, Katarzyna
Machcińska, Maja
Brodaczewska, Klaudia
Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells
title Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells
title_full Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells
title_fullStr Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells
title_full_unstemmed Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells
title_short Intestinal Nematode Infection Affects Metastasis of EL4 Lymphoma Cells
title_sort intestinal nematode infection affects metastasis of el4 lymphoma cells
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508930/
https://www.ncbi.nlm.nih.gov/pubmed/32960348
http://dx.doi.org/10.1007/s00005-020-00594-2
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AT machcinskamaja intestinalnematodeinfectionaffectsmetastasisofel4lymphomacells
AT brodaczewskaklaudia intestinalnematodeinfectionaffectsmetastasisofel4lymphomacells

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