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Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems
Photoperiod or the duration of daylight has been implicated as a risk factor in the development of mood disorders. The dopamine and serotonin systems are impacted by photoperiod and are consistently associated with affective disorders. Hence, we evaluated, at multiple stages of postnatal development...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508939/ https://www.ncbi.nlm.nih.gov/pubmed/32963273 http://dx.doi.org/10.1038/s41598-020-72263-5 |
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author | Siemann, Justin K. Williams, Piper Malik, Turnee N. Jackson, Chad R. Green, Noah H. Emeson, Ronald B. Levitt, Pat McMahon, Douglas G. |
author_facet | Siemann, Justin K. Williams, Piper Malik, Turnee N. Jackson, Chad R. Green, Noah H. Emeson, Ronald B. Levitt, Pat McMahon, Douglas G. |
author_sort | Siemann, Justin K. |
collection | PubMed |
description | Photoperiod or the duration of daylight has been implicated as a risk factor in the development of mood disorders. The dopamine and serotonin systems are impacted by photoperiod and are consistently associated with affective disorders. Hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (TH) and serotonergic (Tph2, SERT, and Pet-1) genes, and midbrain monoamine content in mice raised under control Equinox (LD 12:12), Short winter-like (LD 8:16), or Long summer-like (LD 16:8) photoperiods. Focusing in early adulthood, we evaluated the midbrain levels of these serotonergic genes, and also assayed these gene levels in the dorsal raphe nucleus (DRN) with RNAScope. Mice that developed under Short photoperiods demonstrated elevated midbrain TH expression levels, specifically during perinatal development compared to mice raised under Long photoperiods, and significantly decreased serotonin and dopamine content throughout the course of development. In adulthood, Long photoperiod mice demonstrated decreased midbrain Tph2 and SERT expression levels and reduced Tph2 levels in the DRN compared Short photoperiod mice. Thus, evaluating gene × environment interactions in the dopaminergic and serotonergic systems during multiple stages of development may lead to novel insights into the underlying mechanisms in the development of affective disorders. |
format | Online Article Text |
id | pubmed-7508939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75089392020-09-24 Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems Siemann, Justin K. Williams, Piper Malik, Turnee N. Jackson, Chad R. Green, Noah H. Emeson, Ronald B. Levitt, Pat McMahon, Douglas G. Sci Rep Article Photoperiod or the duration of daylight has been implicated as a risk factor in the development of mood disorders. The dopamine and serotonin systems are impacted by photoperiod and are consistently associated with affective disorders. Hence, we evaluated, at multiple stages of postnatal development, the expression of key dopaminergic (TH) and serotonergic (Tph2, SERT, and Pet-1) genes, and midbrain monoamine content in mice raised under control Equinox (LD 12:12), Short winter-like (LD 8:16), or Long summer-like (LD 16:8) photoperiods. Focusing in early adulthood, we evaluated the midbrain levels of these serotonergic genes, and also assayed these gene levels in the dorsal raphe nucleus (DRN) with RNAScope. Mice that developed under Short photoperiods demonstrated elevated midbrain TH expression levels, specifically during perinatal development compared to mice raised under Long photoperiods, and significantly decreased serotonin and dopamine content throughout the course of development. In adulthood, Long photoperiod mice demonstrated decreased midbrain Tph2 and SERT expression levels and reduced Tph2 levels in the DRN compared Short photoperiod mice. Thus, evaluating gene × environment interactions in the dopaminergic and serotonergic systems during multiple stages of development may lead to novel insights into the underlying mechanisms in the development of affective disorders. Nature Publishing Group UK 2020-09-22 /pmc/articles/PMC7508939/ /pubmed/32963273 http://dx.doi.org/10.1038/s41598-020-72263-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Siemann, Justin K. Williams, Piper Malik, Turnee N. Jackson, Chad R. Green, Noah H. Emeson, Ronald B. Levitt, Pat McMahon, Douglas G. Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems |
title | Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems |
title_full | Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems |
title_fullStr | Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems |
title_full_unstemmed | Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems |
title_short | Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems |
title_sort | photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508939/ https://www.ncbi.nlm.nih.gov/pubmed/32963273 http://dx.doi.org/10.1038/s41598-020-72263-5 |
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