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Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects

INTRODUCTION: Reduced muscle strength is a high risk factor for type 2 diabetes mellitus, and this association is especially strong in non-obese male individuals. However, it remains unclear how reduced muscle strength affects susceptibility to diabetes. We have examined whether lower limb muscle st...

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Autores principales: Someya, Yuki, Tamura, Yoshifumi, Takeno, Kageumi, Kakehi, Saori, Funayama, Takashi, Furukawa, Yasuhiko, Eshima, Hiroaki, Watanabe, Keisuke, Kurihara, Toshiyuki, Yanagiya, Toshio, Kaga, Hideyoshi, Suzuki, Ruriko, Sugimoto, Daisuke, Kadowaki, Satoshi, Kawamori, Ryuzo, Watada, Hirotaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509026/
https://www.ncbi.nlm.nih.gov/pubmed/32767276
http://dx.doi.org/10.1007/s13300-020-00895-x
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author Someya, Yuki
Tamura, Yoshifumi
Takeno, Kageumi
Kakehi, Saori
Funayama, Takashi
Furukawa, Yasuhiko
Eshima, Hiroaki
Watanabe, Keisuke
Kurihara, Toshiyuki
Yanagiya, Toshio
Kaga, Hideyoshi
Suzuki, Ruriko
Sugimoto, Daisuke
Kadowaki, Satoshi
Kawamori, Ryuzo
Watada, Hirotaka
author_facet Someya, Yuki
Tamura, Yoshifumi
Takeno, Kageumi
Kakehi, Saori
Funayama, Takashi
Furukawa, Yasuhiko
Eshima, Hiroaki
Watanabe, Keisuke
Kurihara, Toshiyuki
Yanagiya, Toshio
Kaga, Hideyoshi
Suzuki, Ruriko
Sugimoto, Daisuke
Kadowaki, Satoshi
Kawamori, Ryuzo
Watada, Hirotaka
author_sort Someya, Yuki
collection PubMed
description INTRODUCTION: Reduced muscle strength is a high risk factor for type 2 diabetes mellitus, and this association is especially strong in non-obese male individuals. However, it remains unclear how reduced muscle strength affects susceptibility to diabetes. We have examined whether lower limb muscle strength is associated with insulin resistance in non-obese Japanese male subjects. METHODS: Measurements from 64 non-diabetic, non-obese, middle-aged Japanese men were analyzed. Insulin sensitivity in muscle was measured using the hyperinsulinemic-euglycemic clamp. Isometric muscle strength of the knee extensor and flexor muscles was evaluated using a dynameter. RESULTS: Lower muscle strength of knee flexors, but not knee extensors, was associated with impaired muscle insulin sensitivity (knee flexor muscles: low, medium, and high strength was 6.6 ± 2.2, 7.3 ± 2.0, and 8.8 ± 2.2 mg/kg per minute, respectively, p for trend < 0.05; knee extensor muscles: low, medium, and high strength was 7.3 ± 2.5, 7.5 ± 2.2, and 7.8 ± 2.3 mg/kg per minute, respectively, p for trend = 0.73). Knee flexor muscle strength was also identified as an independent determinant of insulin sensitivity in the multiple regression analysis (β = 0.274, p = 0.036). CONCLUSIONS: Diminished strength of knee flexor muscles, but not knee extensor muscles, was associated with muscle insulin sensitivity in non-diabetic, non-obese Japanese male subjects.
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spelling pubmed-75090262020-10-05 Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects Someya, Yuki Tamura, Yoshifumi Takeno, Kageumi Kakehi, Saori Funayama, Takashi Furukawa, Yasuhiko Eshima, Hiroaki Watanabe, Keisuke Kurihara, Toshiyuki Yanagiya, Toshio Kaga, Hideyoshi Suzuki, Ruriko Sugimoto, Daisuke Kadowaki, Satoshi Kawamori, Ryuzo Watada, Hirotaka Diabetes Ther Brief Report INTRODUCTION: Reduced muscle strength is a high risk factor for type 2 diabetes mellitus, and this association is especially strong in non-obese male individuals. However, it remains unclear how reduced muscle strength affects susceptibility to diabetes. We have examined whether lower limb muscle strength is associated with insulin resistance in non-obese Japanese male subjects. METHODS: Measurements from 64 non-diabetic, non-obese, middle-aged Japanese men were analyzed. Insulin sensitivity in muscle was measured using the hyperinsulinemic-euglycemic clamp. Isometric muscle strength of the knee extensor and flexor muscles was evaluated using a dynameter. RESULTS: Lower muscle strength of knee flexors, but not knee extensors, was associated with impaired muscle insulin sensitivity (knee flexor muscles: low, medium, and high strength was 6.6 ± 2.2, 7.3 ± 2.0, and 8.8 ± 2.2 mg/kg per minute, respectively, p for trend < 0.05; knee extensor muscles: low, medium, and high strength was 7.3 ± 2.5, 7.5 ± 2.2, and 7.8 ± 2.3 mg/kg per minute, respectively, p for trend = 0.73). Knee flexor muscle strength was also identified as an independent determinant of insulin sensitivity in the multiple regression analysis (β = 0.274, p = 0.036). CONCLUSIONS: Diminished strength of knee flexor muscles, but not knee extensor muscles, was associated with muscle insulin sensitivity in non-diabetic, non-obese Japanese male subjects. Springer Healthcare 2020-08-07 2020-10 /pmc/articles/PMC7509026/ /pubmed/32767276 http://dx.doi.org/10.1007/s13300-020-00895-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Report
Someya, Yuki
Tamura, Yoshifumi
Takeno, Kageumi
Kakehi, Saori
Funayama, Takashi
Furukawa, Yasuhiko
Eshima, Hiroaki
Watanabe, Keisuke
Kurihara, Toshiyuki
Yanagiya, Toshio
Kaga, Hideyoshi
Suzuki, Ruriko
Sugimoto, Daisuke
Kadowaki, Satoshi
Kawamori, Ryuzo
Watada, Hirotaka
Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects
title Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects
title_full Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects
title_fullStr Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects
title_full_unstemmed Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects
title_short Decreased Muscle Strength of Knee Flexors is Associated with Impaired Muscle Insulin Sensitivity in Non-Diabetic Middle-Aged Japanese Male Subjects
title_sort decreased muscle strength of knee flexors is associated with impaired muscle insulin sensitivity in non-diabetic middle-aged japanese male subjects
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509026/
https://www.ncbi.nlm.nih.gov/pubmed/32767276
http://dx.doi.org/10.1007/s13300-020-00895-x
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