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Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation o...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509053/ https://www.ncbi.nlm.nih.gov/pubmed/33013710 http://dx.doi.org/10.3389/fendo.2020.00641 |
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author | Dewailly, Didier Barbotin, Anne-Laure Dumont, Agathe Catteau-Jonard, Sophie Robin, Geoffroy |
author_facet | Dewailly, Didier Barbotin, Anne-Laure Dumont, Agathe Catteau-Jonard, Sophie Robin, Geoffroy |
author_sort | Dewailly, Didier |
collection | PubMed |
description | Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed. |
format | Online Article Text |
id | pubmed-7509053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75090532020-10-02 Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome Dewailly, Didier Barbotin, Anne-Laure Dumont, Agathe Catteau-Jonard, Sophie Robin, Geoffroy Front Endocrinol (Lausanne) Endocrinology Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed. Frontiers Media S.A. 2020-09-09 /pmc/articles/PMC7509053/ /pubmed/33013710 http://dx.doi.org/10.3389/fendo.2020.00641 Text en Copyright © 2020 Dewailly, Barbotin, Dumont, Catteau-Jonard and Robin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Dewailly, Didier Barbotin, Anne-Laure Dumont, Agathe Catteau-Jonard, Sophie Robin, Geoffroy Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome |
title | Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome |
title_full | Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome |
title_fullStr | Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome |
title_full_unstemmed | Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome |
title_short | Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome |
title_sort | role of anti-müllerian hormone in the pathogenesis of polycystic ovary syndrome |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509053/ https://www.ncbi.nlm.nih.gov/pubmed/33013710 http://dx.doi.org/10.3389/fendo.2020.00641 |
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