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Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation o...

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Autores principales: Dewailly, Didier, Barbotin, Anne-Laure, Dumont, Agathe, Catteau-Jonard, Sophie, Robin, Geoffroy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509053/
https://www.ncbi.nlm.nih.gov/pubmed/33013710
http://dx.doi.org/10.3389/fendo.2020.00641
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author Dewailly, Didier
Barbotin, Anne-Laure
Dumont, Agathe
Catteau-Jonard, Sophie
Robin, Geoffroy
author_facet Dewailly, Didier
Barbotin, Anne-Laure
Dumont, Agathe
Catteau-Jonard, Sophie
Robin, Geoffroy
author_sort Dewailly, Didier
collection PubMed
description Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.
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spelling pubmed-75090532020-10-02 Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome Dewailly, Didier Barbotin, Anne-Laure Dumont, Agathe Catteau-Jonard, Sophie Robin, Geoffroy Front Endocrinol (Lausanne) Endocrinology Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed. Frontiers Media S.A. 2020-09-09 /pmc/articles/PMC7509053/ /pubmed/33013710 http://dx.doi.org/10.3389/fendo.2020.00641 Text en Copyright © 2020 Dewailly, Barbotin, Dumont, Catteau-Jonard and Robin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Dewailly, Didier
Barbotin, Anne-Laure
Dumont, Agathe
Catteau-Jonard, Sophie
Robin, Geoffroy
Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
title Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
title_full Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
title_fullStr Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
title_full_unstemmed Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
title_short Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome
title_sort role of anti-müllerian hormone in the pathogenesis of polycystic ovary syndrome
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509053/
https://www.ncbi.nlm.nih.gov/pubmed/33013710
http://dx.doi.org/10.3389/fendo.2020.00641
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