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PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance

The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular processes, including the regulation of transcription, apoptosis and the DNA damage response. PARP1 possesses Poly (ADP-ribose) activity and when activated by DNA damage, adds branched PAR chains to facilitate the...

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Detalles Bibliográficos
Autores principales:	Rose, Maddison, Burgess, Joshua T., O’Byrne, Kenneth, Richard, Derek J., Bolderson, Emma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509090/ https://www.ncbi.nlm.nih.gov/pubmed/33015058 http://dx.doi.org/10.3389/fcell.2020.564601

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