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Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report

BACKGROUND: Fahr’s syndrome (or Fahr’s disease) is a rare, neurological disorder characterized by bilateral calcification in the cerebellum, thalamus, basal ganglia, and cerebral cortex as a result of calcium and phosphorus metabolism disorder. The patients may be asymptomatic and clinical symptoms...

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Autores principales: Demir, Gürkan, Balaban, Onur, Tekeci, Muhammet Halit, Issı, Zeynep, Erdem, Ali Fuat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509223/
https://www.ncbi.nlm.nih.gov/pubmed/32965525
http://dx.doi.org/10.1007/s10072-020-04733-7
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author Demir, Gürkan
Balaban, Onur
Tekeci, Muhammet Halit
Issı, Zeynep
Erdem, Ali Fuat
author_facet Demir, Gürkan
Balaban, Onur
Tekeci, Muhammet Halit
Issı, Zeynep
Erdem, Ali Fuat
author_sort Demir, Gürkan
collection PubMed
description BACKGROUND: Fahr’s syndrome (or Fahr’s disease) is a rare, neurological disorder characterized by bilateral calcification in the cerebellum, thalamus, basal ganglia, and cerebral cortex as a result of calcium and phosphorus metabolism disorder. The patients may be asymptomatic and clinical symptoms represent a wide range of neurologic manifestations and nonspecific neuropsychiatric disorders. We report an unusual case of Fahr’s syndrome which was asymptomatic and incidentally diagnosed by generalized tonic-clonic seizure in a patient with SARS-CoV-2 (COVİD-19) pneumonia. CASE PRESENTATION: The patient was a 68-year-old female and admitted to our emergency department suffering from cough and fatigue. After thorax computed tomography (CT) and SARS-CoV-2 PCR test, she was diagnosed as COVID-19 pneumonia. In the intensive care unit, the patient had a tonic-clonic convulsion starting from the left arm and spreading to the whole body. Fahr’s syndrome was diagnosed after a cranial CT scan and blood metabolic panel test. CONCLUSIONS: As a result of the clinical, radiological, and biochemical evaluations, the patient was diagnosed incidentally as Fahr’s syndrome associated with hypoparathyroidism. Seizures could be induced by hydroxychloroquine that was in the COVID-19 treatment or the inflammation caused by COVID-19 pneumonia. The association between the mortality of COVID-19 pneumonia and Fahr’s syndrome is unknown which needs further research.
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spelling pubmed-75092232020-09-23 Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report Demir, Gürkan Balaban, Onur Tekeci, Muhammet Halit Issı, Zeynep Erdem, Ali Fuat Neurol Sci Covid-19 BACKGROUND: Fahr’s syndrome (or Fahr’s disease) is a rare, neurological disorder characterized by bilateral calcification in the cerebellum, thalamus, basal ganglia, and cerebral cortex as a result of calcium and phosphorus metabolism disorder. The patients may be asymptomatic and clinical symptoms represent a wide range of neurologic manifestations and nonspecific neuropsychiatric disorders. We report an unusual case of Fahr’s syndrome which was asymptomatic and incidentally diagnosed by generalized tonic-clonic seizure in a patient with SARS-CoV-2 (COVİD-19) pneumonia. CASE PRESENTATION: The patient was a 68-year-old female and admitted to our emergency department suffering from cough and fatigue. After thorax computed tomography (CT) and SARS-CoV-2 PCR test, she was diagnosed as COVID-19 pneumonia. In the intensive care unit, the patient had a tonic-clonic convulsion starting from the left arm and spreading to the whole body. Fahr’s syndrome was diagnosed after a cranial CT scan and blood metabolic panel test. CONCLUSIONS: As a result of the clinical, radiological, and biochemical evaluations, the patient was diagnosed incidentally as Fahr’s syndrome associated with hypoparathyroidism. Seizures could be induced by hydroxychloroquine that was in the COVID-19 treatment or the inflammation caused by COVID-19 pneumonia. The association between the mortality of COVID-19 pneumonia and Fahr’s syndrome is unknown which needs further research. Springer International Publishing 2020-09-23 2020 /pmc/articles/PMC7509223/ /pubmed/32965525 http://dx.doi.org/10.1007/s10072-020-04733-7 Text en © Fondazione Società Italiana di Neurologia 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Covid-19
Demir, Gürkan
Balaban, Onur
Tekeci, Muhammet Halit
Issı, Zeynep
Erdem, Ali Fuat
Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report
title Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report
title_full Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report
title_fullStr Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report
title_full_unstemmed Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report
title_short Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report
title_sort fahr’s syndrome presenting with seizures in sars-cov-2 (covid-19) pneumonia—a case report
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509223/
https://www.ncbi.nlm.nih.gov/pubmed/32965525
http://dx.doi.org/10.1007/s10072-020-04733-7
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