Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country

Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype analysis of 6,356 US isolates, we identified a pattern of strongly localized outbreaks at the city-, state-, and country-levels, and temporal...

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Autores principales: Shen, Lishuang, Dien Bard, Jennifer, Biegel, Jaclyn A., Judkins, Alexander R., Gai, Xiaowu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509426/
https://www.ncbi.nlm.nih.gov/pubmed/33013809
http://dx.doi.org/10.3389/fmicb.2020.573430
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author Shen, Lishuang
Dien Bard, Jennifer
Biegel, Jaclyn A.
Judkins, Alexander R.
Gai, Xiaowu
author_facet Shen, Lishuang
Dien Bard, Jennifer
Biegel, Jaclyn A.
Judkins, Alexander R.
Gai, Xiaowu
author_sort Shen, Lishuang
collection PubMed
description Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype analysis of 6,356 US isolates, we identified a pattern of strongly localized outbreaks at the city-, state-, and country-levels, and temporal transmissions. This points to the effectiveness of existing travel restriction policies and public health measures in reducing the transmission of SARS-CoV-2.
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spelling pubmed-75094262020-10-02 Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country Shen, Lishuang Dien Bard, Jennifer Biegel, Jaclyn A. Judkins, Alexander R. Gai, Xiaowu Front Microbiol Microbiology Genomic analysis of SARS-CoV-2 sequences is crucial in determining the effectiveness of prudent safer at home measures in the United States (US). By haplotype analysis of 6,356 US isolates, we identified a pattern of strongly localized outbreaks at the city-, state-, and country-levels, and temporal transmissions. This points to the effectiveness of existing travel restriction policies and public health measures in reducing the transmission of SARS-CoV-2. Frontiers Media S.A. 2020-09-03 /pmc/articles/PMC7509426/ /pubmed/33013809 http://dx.doi.org/10.3389/fmicb.2020.573430 Text en Copyright © 2020 Shen, Dien Bard, Biegel, Judkins and Gai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Shen, Lishuang
Dien Bard, Jennifer
Biegel, Jaclyn A.
Judkins, Alexander R.
Gai, Xiaowu
Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country
title Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country
title_full Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country
title_fullStr Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country
title_full_unstemmed Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country
title_short Comprehensive Genome Analysis of 6,000 USA SARS-CoV-2 Isolates Reveals Haplotype Signatures and Localized Transmission Patterns by State and by Country
title_sort comprehensive genome analysis of 6,000 usa sars-cov-2 isolates reveals haplotype signatures and localized transmission patterns by state and by country
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509426/
https://www.ncbi.nlm.nih.gov/pubmed/33013809
http://dx.doi.org/10.3389/fmicb.2020.573430
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