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Upregulation of Prickle2 Ameliorates Alzheimer’s Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder that has no effective therapies. Prickle planar cell polarity protein 2 (Prickle2), is an important cytoplasmic regulator of Wnt/PCP signaling. It has been reported that Prickle2 deficiency reduced neurite outgrowth levels in mouse...

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Detalles Bibliográficos
Autores principales:	Sun, Fengxian, Jiang, Fang, Zhang, Na, Li, Hua, Tian, Weiping, Liu, Weiying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509431/ https://www.ncbi.nlm.nih.gov/pubmed/33015060 http://dx.doi.org/10.3389/fcell.2020.565020

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