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Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience

Background: Studies have shown that patients with a thin endometrial thickness (EMT < 7 or 8 mm) during IVF/ICSI tend to have adverse pregnancy outcomes, and this has caused much anxiety to both patients and physicians when confronted with a thin EMT. Method: From January 2015 to December 2018, p...

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Detalles Bibliográficos
Autores principales: Bu, Zhiqin, Hu, Linli, Yang, Xinhong, Sun, Yingpu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509444/
https://www.ncbi.nlm.nih.gov/pubmed/33013679
http://dx.doi.org/10.3389/fendo.2020.00469
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author Bu, Zhiqin
Hu, Linli
Yang, Xinhong
Sun, Yingpu
author_facet Bu, Zhiqin
Hu, Linli
Yang, Xinhong
Sun, Yingpu
author_sort Bu, Zhiqin
collection PubMed
description Background: Studies have shown that patients with a thin endometrial thickness (EMT < 7 or 8 mm) during IVF/ICSI tend to have adverse pregnancy outcomes, and this has caused much anxiety to both patients and physicians when confronted with a thin EMT. Method: From January 2015 to December 2018, patients with a thin EMT < 7 mm on the day of hCG administration during their first GnRH agonist IVF/ICSI cycle were included. According to the hysteroscopy results, patients were classified into totally normal (Group A), normal with a specific abnormality (Group B), and adhesion before transfer (Group C). Result: For the 245 patients included, approximately 60% of the thin EMT cases were the result of an intrauterine operation. CLBR was 35.45% (67/189) in this group of patients. In regard to CLBR, there were significant differences among these three uterus condition groups irrespective of the number of oocytes retrieved (28.57 vs. 10.00 vs. 4.76%, P = 0.12 in oocyte ≤5; 61.36 vs. 44.67 vs. 23.63%, P = 0.00 in oocyte >5). In binary logistic regression analysis, age (OR = 0.09, P = 0.03), number of embryos available (OR = 1.71, P = 0.00), and uterine condition (OR = 6.77, P = 0.00 for group A; OR = 2.55, P = 0.04 for group B; Reference = group C), were significantly associated with CLBR. However, EMT and endometrial pattern had no impact on CLBR. Conclusion: An intrauterine operation was the main reason for a thin EMT. Thin EMT patients with a normal uterine cavity and endometrium had a significantly better CLBR compared with those with adhesions before transfer.
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spelling pubmed-75094442020-10-02 Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience Bu, Zhiqin Hu, Linli Yang, Xinhong Sun, Yingpu Front Endocrinol (Lausanne) Endocrinology Background: Studies have shown that patients with a thin endometrial thickness (EMT < 7 or 8 mm) during IVF/ICSI tend to have adverse pregnancy outcomes, and this has caused much anxiety to both patients and physicians when confronted with a thin EMT. Method: From January 2015 to December 2018, patients with a thin EMT < 7 mm on the day of hCG administration during their first GnRH agonist IVF/ICSI cycle were included. According to the hysteroscopy results, patients were classified into totally normal (Group A), normal with a specific abnormality (Group B), and adhesion before transfer (Group C). Result: For the 245 patients included, approximately 60% of the thin EMT cases were the result of an intrauterine operation. CLBR was 35.45% (67/189) in this group of patients. In regard to CLBR, there were significant differences among these three uterus condition groups irrespective of the number of oocytes retrieved (28.57 vs. 10.00 vs. 4.76%, P = 0.12 in oocyte ≤5; 61.36 vs. 44.67 vs. 23.63%, P = 0.00 in oocyte >5). In binary logistic regression analysis, age (OR = 0.09, P = 0.03), number of embryos available (OR = 1.71, P = 0.00), and uterine condition (OR = 6.77, P = 0.00 for group A; OR = 2.55, P = 0.04 for group B; Reference = group C), were significantly associated with CLBR. However, EMT and endometrial pattern had no impact on CLBR. Conclusion: An intrauterine operation was the main reason for a thin EMT. Thin EMT patients with a normal uterine cavity and endometrium had a significantly better CLBR compared with those with adhesions before transfer. Frontiers Media S.A. 2020-09-04 /pmc/articles/PMC7509444/ /pubmed/33013679 http://dx.doi.org/10.3389/fendo.2020.00469 Text en Copyright © 2020 Bu, Hu, Yang and Sun. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Bu, Zhiqin
Hu, Linli
Yang, Xinhong
Sun, Yingpu
Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience
title Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience
title_full Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience
title_fullStr Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience
title_full_unstemmed Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience
title_short Cumulative Live Birth Rate in Patients With Thin Endometrium: A Real-World Single-Center Experience
title_sort cumulative live birth rate in patients with thin endometrium: a real-world single-center experience
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509444/
https://www.ncbi.nlm.nih.gov/pubmed/33013679
http://dx.doi.org/10.3389/fendo.2020.00469
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