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Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases
Autophagy has dual effects in human diseases: appropriate autophagy may protect cells from stress, while excessive autophagy may cause cell death. Additionally, close interactions exist between autophagy and the Golgi. This review outlines recent advances regarding the role of the Golgi apparatus in...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509445/ https://www.ncbi.nlm.nih.gov/pubmed/33015059 http://dx.doi.org/10.3389/fcell.2020.564975 |
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author | Deng, Shuwen Liu, Jia Wu, Xiaomei Lu, Wei |
author_facet | Deng, Shuwen Liu, Jia Wu, Xiaomei Lu, Wei |
author_sort | Deng, Shuwen |
collection | PubMed |
description | Autophagy has dual effects in human diseases: appropriate autophagy may protect cells from stress, while excessive autophagy may cause cell death. Additionally, close interactions exist between autophagy and the Golgi. This review outlines recent advances regarding the role of the Golgi apparatus in autophagy. The signaling processes of autophagy are dependent on the normal function of the Golgi. Specifically, (i) autophagy-related protein 9 is mainly located in the Golgi and forms new autophagosomes in response to stressors; (ii) Golgi fragmentation is induced by Golgi-related proteins and accompanied with autophagy induction; and (iii) the endoplasmic reticulum-Golgi intermediate compartment and the reticular trans-Golgi network play essential roles in autophagosome formation to provide a template for lipidation of microtubule-associated protein 1A/1B-light chain 3 and induce further ubiquitination. Golgi-related proteins regulate formation of autophagosomes, and disrupted formation of autophagy can influence Golgi function. Notably, aberrant autophagy has been demonstrated to be implicated in neurological diseases. Thus, targeted therapies aimed at protecting the Golgi or regulating Golgi proteins might prevent or ameliorate autophagy-related neurological diseases. Further studies are needed to investigate the potential application of Golgi therapy in autophagy-based neurological diseases. |
format | Online Article Text |
id | pubmed-7509445 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75094452020-10-02 Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases Deng, Shuwen Liu, Jia Wu, Xiaomei Lu, Wei Front Cell Dev Biol Cell and Developmental Biology Autophagy has dual effects in human diseases: appropriate autophagy may protect cells from stress, while excessive autophagy may cause cell death. Additionally, close interactions exist between autophagy and the Golgi. This review outlines recent advances regarding the role of the Golgi apparatus in autophagy. The signaling processes of autophagy are dependent on the normal function of the Golgi. Specifically, (i) autophagy-related protein 9 is mainly located in the Golgi and forms new autophagosomes in response to stressors; (ii) Golgi fragmentation is induced by Golgi-related proteins and accompanied with autophagy induction; and (iii) the endoplasmic reticulum-Golgi intermediate compartment and the reticular trans-Golgi network play essential roles in autophagosome formation to provide a template for lipidation of microtubule-associated protein 1A/1B-light chain 3 and induce further ubiquitination. Golgi-related proteins regulate formation of autophagosomes, and disrupted formation of autophagy can influence Golgi function. Notably, aberrant autophagy has been demonstrated to be implicated in neurological diseases. Thus, targeted therapies aimed at protecting the Golgi or regulating Golgi proteins might prevent or ameliorate autophagy-related neurological diseases. Further studies are needed to investigate the potential application of Golgi therapy in autophagy-based neurological diseases. Frontiers Media S.A. 2020-09-09 /pmc/articles/PMC7509445/ /pubmed/33015059 http://dx.doi.org/10.3389/fcell.2020.564975 Text en Copyright © 2020 Deng, Liu, Wu and Lu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Deng, Shuwen Liu, Jia Wu, Xiaomei Lu, Wei Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases |
title | Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases |
title_full | Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases |
title_fullStr | Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases |
title_full_unstemmed | Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases |
title_short | Golgi Apparatus: A Potential Therapeutic Target for Autophagy-Associated Neurological Diseases |
title_sort | golgi apparatus: a potential therapeutic target for autophagy-associated neurological diseases |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509445/ https://www.ncbi.nlm.nih.gov/pubmed/33015059 http://dx.doi.org/10.3389/fcell.2020.564975 |
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